4-[(1-氰基环丁基)氨基]-2-氟-N-甲基苯甲酰胺合成路线 （共 6 条）
反应条件
1: in N,N-dimethyl acetamide T=60°C; 2: With hydrogenchloride in methanol; N,N-dimethyl acetamide; water 2 h; Heating / reflux; Product distribution / selectivity;
参考文献
SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH
Patent: WO2008/119015 A2, 2008 ;
Location in patent: Page/Page column 54 ;
反应条件
in water; acetic acid
T=80°C; 24 h;
参考文献
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Patent: WO2006/124118 A1, 2006 ;
Location in patent: Page/Page column 73 ;
反应条件
acetic acid
T=80°C; 24 h;
参考文献
TONG, Youzhi
Patent: WO2011/29392 A1, 2011 ;
Location in patent: Page/Page column 63 ;
WO 2011/029392 A1
反应条件
in acetic acid
T=80°C;
参考文献
ARAGON PHARMACEUTICALS, INC.; SMITH, Nicholas, D.; BONNEFOUS, Celine; JULIEN, Jackaline, D.
Patent: WO2011/103202 A2, 2011 ;
Location in patent: Page/Page column 167 ;
WO 2011/103202 A2
反应条件
1.1: thionyl chloride / N,N-dimethyl-formamide / 1 h / -5 °C
1.2: 0 - 25 °C
2.1: acetic acid / iron / ethyl acetate / Reflux
3.1: acetic acid / 24 h / 80 °C
View Scheme
参考文献
TONG, Youzhi
Patent: WO2011/29392 A1, 2011 ;
WO 2011/029392 A1
反应条件
1: acetic acid / iron / ethyl acetate / Reflux
2: acetic acid / 24 h / 80 °C
View Scheme
参考文献
TONG, Youzhi
Patent: WO2011/29392 A1, 2011 ;
WO 2011/029392 A1
