反应条件
1: methyllithium With copper(l) iodide in diethyl ether
T=0°C; 0.0833333 h; Inert atmosphere;
2: (2Z,6E)-3-(Diethoxy-phosphoryloxy)-7,11-dimethyl-dodeca-2,6,10-trienoic acid methyl ester in diethyl ether
T=-78 - -30°C; 2 h; Inert atmosphere;
参考文献
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK; SNYDER, Scott, Alan; TREITLER, Daniel, S.; BRUCKS, Alexandria, P.; GOLLNER, Andreas; CHIRIAC, Maria, I.; WRIGHT, Nathan, E.; PFLUEGER, Jason, J.; BREAZZANO, Steven, P.
Patent: WO2012/37069 A2, 2012 ;
Location in patent: Page/Page column 116 ;
