4-(苄氧基甲基)-4-氰基哌啶-1-羧酸叔丁酯合成路线 （共 5 条）
反应条件
1: 4-cyano-1-piperidinecarboxylic acid,1,1-dimethyl-ethylester With potassium hexamethylsilazane in tetrahydrofuran
T=25°C;
2: chloromethyl benzyl ether in tetrahydrofuran
参考文献
Zhao, Zhijian; O'Brien, Julie A.; Lemaire, Wei; Williams Jr., David L.; Jacobson, Marlene A.; Sur, Cyrille; Pettibone, Doug J.; Tiller, Philip R.; Smith, Sheri; Hartman, George D.; Wolkenberg, Scott E.; Lindsley, Craig W.
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 23 p. 5968 - 5972
反应条件
1.1: dichloromethane / 1 h / 0 - 20 °C
2.1: potassium hexamethylsilazane / toluene; tetrahydrofuran / 1 h / 0 - 20 °C
2.2: 1 h / 20 °C
View Scheme
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOYER, Stephen, James; GAO, Donghong, Amy; GUO, Xin; KIRRANE, Thomas, Martin, Jr.; SARKO, Christopher, Ronald; SNOW, Roger, John; SOLEYMANZADEH, Fariba; ZHANG, Yunlong
Patent: WO2011/71716 A1, 2011 ;
WO 2011/071716 A1
反应条件
1.1: dichloromethane / 1 h / 0 - 20 °C
2.1: potassium hexamethylsilazane / toluene; tetrahydrofuran / 1 h / 0 - 20 °C
2.2: 1 h / 20 °C
View Scheme
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOYER, Stephen, James; GAO, Donghong, Amy; GUO, Xin; KIRRANE, Thomas, Martin, Jr.; SARKO, Christopher, Ronald; SNOW, Roger, John; SOLEYMANZADEH, Fariba; ZHANG, Yunlong
Patent: WO2011/71716 A1, 2011 ;
WO 2011/071716 A1
反应条件
hydrogenchloride in 1,4-dioxane
参考文献
Zhao, Zhijian; O'Brien, Julie A.; Lemaire, Wei; Williams Jr., David L.; Jacobson, Marlene A.; Sur, Cyrille; Pettibone, Doug J.; Tiller, Philip R.; Smith, Sheri; Hartman, George D.; Wolkenberg, Scott E.; Lindsley, Craig W.
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 23 p. 5968 - 5972
反应条件
1: 100 percent / HCl / dioxane
2: 95 percent / i-Pr2NEt / CH2Cl2 / 0 - 25 °C
View Scheme
参考文献
Zhao, Zhijian; O'Brien, Julie A.; Lemaire, Wei; Williams Jr., David L.; Jacobson, Marlene A.; Sur, Cyrille; Pettibone, Doug J.; Tiller, Philip R.; Smith, Sheri; Hartman, George D.; Wolkenberg, Scott E.; Lindsley, Craig W.
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 23 p. 5968 - 5972
