2-(4-苄氧基-苯基)-N,N-二甲基-乙酰胺合成路线 (共 3 条)
反应条件
1: 2-(4-benzyloxy-phenyl)-N,N-dimethyl-acetamide With isopropylmagnesium chloride in tetrahydrofuran T=5 - 35°C; 1 h; 2: cyclohexanone in tetrahydrofuran T=5 - 35°C; 0.283333 - 1 h; 3: With sodium hydroxide; water; sodium bis(2-methoxyethoxy)aluminium dihydride; citric acid Product distribution / selectivity; more than 3 stages;
参考文献
SEPRACOR INC.
Patent: WO2008/103461 A2, 2008 ;
Location in patent: Page/Page column 66-68 ;
反应条件
1: (4-benzyloxy-phenyl)-acetic acid With thionyl chloride; N,N-dimethyl-formamide in dichloromethane
6 h; Heating / reflux;
2: dimethylammonium chloride With triethylamine in dichloromethane
T=5 - 10°C; 1 h;
参考文献
GENERICS [UK] LIMITED; MERCK DEVELOPMENT CENTRE PRIVATE LIMITED
Patent: WO2008/93142 A1, 2008 ;
Location in patent: Page/Page column title page; 11; Sheet 3/3 ;
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=20 - 60°C; 97 h;
参考文献
Wyeth
Patent: US2007/15828 A1, 2007 ;
Location in patent: Page/Page column 6; 10 ;