1: pyridine-4-carbaldehyde With lithium hexamethyldisilazane in tetrahydrofuran
T=0°C; 4 h;
2: iso-propylmagnesium bromide in tetrahydrofuran
T=20°C; 16 h;
3: With hydrogenchloride; water in tetrahydrofuran
参考文献
NISSAN CHEMICAL INDUSTRIES, LTD.
Patent: WO2009/57827 A1, 2009 ;
Location in patent: Page/Page column 160 ;
Stas
Bulletin des Societes Chimiques Belges, 1926 , vol. 35, p. 382
Chem. Zentralbl., 1927 , vol. 98, # I p. 715
Full Text Show Details
Blatt; Stone
Journal of the American Chemical Society, 1932 , vol. 54, p. 1496,1498
1: iso-propylmagnesium bromide With cerium(III) chloride in tetrahydrofuran
T=-78°C; 2 h;
2: 1-(morpholin-4-yl)decan-1-one in tetrahydrofuran
T=-78°C; 1.5 h; Further stages.;
参考文献
Badioli, Michele; Ballini, Roberto; Bartolacci, Massimo; Bosica, Giovanna; Torregiani, Elisabetta; Marcantoni, Enrico
The Journal of organic chemistry, 2002 , vol. 67, # 25 p. 8938 - 8942
