1: With hydrogenchloride; tert.-butylnitrite in tetrahydrofuran; water
1.5 h; Cooling with ice;
2: With sodium azide in tetrahydrofuran; water
T=20°C; Cooling with ice;
参考文献
Lombardo, Caterina Maria; Martinez, Iria Sanchez; Haider, Shozeb; Gabelica, Valerie; De Pauw, Edwin; Moses, John E.; Neidle, Stephen
Chemical Communications, 2010 , vol. 46, # 48 p. 9116 - 9118
1.1: 97 percent / ammonium formate; Pd/C / dimethylformamide / 16 h / 20 °C
2.1: aq. HCl; t-BuONO / tetrahydrofuran / 1 h / 0 °C
2.2: 84 percent / NaN3 / tetrahydrofuran; H2O / 0 - 20 °C
View Scheme
参考文献
Moorhouse, Adam D.; Santos, Ana Mafalda; Gunaratnam, Mekala; Moore, Michael; Neidle, Stephen; Moses, John E.
Journal of the American Chemical Society, 2006 , vol. 128, # 50 p. 15972 - 15973
1.1: 90 percent / Et3N / tetrahydrofuran / -15 - 20 °C
2.1: 91 percent / methanol / 0 - 20 °C
3.1: 97 percent / ammonium formate; Pd/C / dimethylformamide / 16 h / 20 °C
4.1: aq. HCl; t-BuONO / tetrahydrofuran / 1 h / 0 °C
4.2: 84 percent / NaN3 / tetrahydrofuran; H2O / 0 - 20 °C
View Scheme
参考文献
Moorhouse, Adam D.; Santos, Ana Mafalda; Gunaratnam, Mekala; Moore, Michael; Neidle, Stephen; Moses, John E.
Journal of the American Chemical Society, 2006 , vol. 128, # 50 p. 15972 - 15973
1.1: 91 percent / methanol / 0 - 20 °C
2.1: 97 percent / ammonium formate; Pd/C / dimethylformamide / 16 h / 20 °C
3.1: aq. HCl; t-BuONO / tetrahydrofuran / 1 h / 0 °C
3.2: 84 percent / NaN3 / tetrahydrofuran; H2O / 0 - 20 °C
View Scheme
参考文献
Moorhouse, Adam D.; Santos, Ana Mafalda; Gunaratnam, Mekala; Moore, Michael; Neidle, Stephen; Moses, John E.
Journal of the American Chemical Society, 2006 , vol. 128, # 50 p. 15972 - 15973
1.1: 91 percent / methanol / 0 - 20 °C
2.1: 97 percent / ammonium formate; Pd/C / dimethylformamide / 16 h / 20 °C
3.1: aq. HCl; t-BuONO / tetrahydrofuran / 1 h / 0 °C
3.2: 84 percent / NaN3 / tetrahydrofuran; H2O / 0 - 20 °C
View Scheme
参考文献
Moorhouse, Adam D.; Santos, Ana Mafalda; Gunaratnam, Mekala; Moore, Michael; Neidle, Stephen; Moses, John E.
Journal of the American Chemical Society, 2006 , vol. 128, # 50 p. 15972 - 15973
