2,3,5,6-四氟对苯二甲醇合成路线 （共 31 条）
反应条件
1: With sodium tetrahydroborate in ethylene glycol dimethyl ether T=20 - 60°C; 8 h; 2: With hydrogenchloride; water in ethylene glycol dimethyl ether; toluene T=25 - 30°C; 7 h; Product distribution / selectivity;
参考文献
EP1978008 A1, ;
Page/Page column 4 ;
参考文献
Showa Denko K.K.
Patent: US6624336 B1, 2003 ;
反应条件
1: 91 percent / NH3 / diethyl ether / 8 h / 0 - 20 °C 2: 89 percent / POCl3 / 6 h / 135 °C 3: 92 percent / KF; 18-crown-6 / dimethylformamide / 6 h / 140 °C 4: 80 percent / H2; H2SO4 / Ni / 48 h / 30 °C 5: 87 percent / aq. H2SO4 / 2 h / 20 °C 6: 52 percent / LiAlH4 / diethyl ether / 2 h / Heating View Scheme
参考文献
Journal of Fluorine Chemistry, , vol. 125, # 3 p. 451 - 454
反应条件
1: 80 percent / H2; H2SO4 / Ni / 48 h / 30 °C 2: 87 percent / aq. H2SO4 / 2 h / 20 °C 3: 52 percent / LiAlH4 / diethyl ether / 2 h / Heating View Scheme
参考文献
Journal of Fluorine Chemistry, , vol. 125, # 3 p. 451 - 454
反应条件
1: 92 percent / KF; 18-crown-6 / dimethylformamide / 6 h / 140 °C 2: 80 percent / H2; H2SO4 / Ni / 48 h / 30 °C 3: 87 percent / aq. H2SO4 / 2 h / 20 °C 4: 52 percent / LiAlH4 / diethyl ether / 2 h / Heating View Scheme
参考文献
Journal of Fluorine Chemistry, , vol. 125, # 3 p. 451 - 454
反应条件
1: 89 percent / POCl3 / 6 h / 135 °C 2: 92 percent / KF; 18-crown-6 / dimethylformamide / 6 h / 140 °C 3: 80 percent / H2; H2SO4 / Ni / 48 h / 30 °C 4: 87 percent / aq. H2SO4 / 2 h / 20 °C 5: 52 percent / LiAlH4 / diethyl ether / 2 h / Heating View Scheme
参考文献
Journal of Fluorine Chemistry, , vol. 125, # 3 p. 451 - 454
反应条件
1: 65 percent / Fe; Cl2 / 24 h / 180 °C 2: 91 percent / NH3 / diethyl ether / 8 h / 0 - 20 °C 3: 89 percent / POCl3 / 6 h / 135 °C 4: 92 percent / KF; 18-crown-6 / dimethylformamide / 6 h / 140 °C 5: 80 percent / H2; H2SO4 / Ni / 48 h / 30 °C 6: 87 percent / aq. H2SO4 / 2 h / 20 °C 7: 52 percent / LiAlH4 / diethyl ether / 2 h / Heating View Scheme
参考文献
Journal of Fluorine Chemistry, , vol. 125, # 3 p. 451 - 454
反应条件
1.1: 89 g / p-TsOH / toluene / 2 h / Heating 2.1: n-BuLi / tetrahydrofuran / -25 °C 2.2: 76 percent / tetrahydrofuran / -25 - 20 °C 3.1: 72 percent / TFA; aq. HCl / 0.33 h / 55 °C 4.1: 83 percent / (CH3)2S*BH3 / tetrahydrofuran / 0.25 h / 0 °C View Scheme
参考文献
Journal of Fluorine Chemistry, , vol. 120, # 1 p. 77 - 84
反应条件
1.1: n-BuLi / tetrahydrofuran / 1 h / -50 °C 1.2: tetrahydrofuran / -50 - 20 °C 2.1: 89 g / p-TsOH / toluene / 2 h / Heating 3.1: n-BuLi / tetrahydrofuran / -25 °C 3.2: 76 percent / tetrahydrofuran / -25 - 20 °C 4.1: 72 percent / TFA; aq. HCl / 0.33 h / 55 °C 5.1: 83 percent / (CH3)2S*BH3 / tetrahydrofuran / 0.25 h / 0 °C View Scheme
参考文献
Journal of Fluorine Chemistry, , vol. 120, # 1 p. 77 - 84
反应条件
1: 87 percent / aq. H2SO4 / 2 h / 20 °C 2: 52 percent / LiAlH4 / diethyl ether / 2 h / Heating View Scheme
参考文献
Journal of Fluorine Chemistry, , vol. 125, # 3 p. 451 - 454
