反应条件
1.1: 67 percent / toluene; 1,2-dichloro-benzene / 0.33 h / 210 °C / microwave irradiation
2.1: 98 percent / aq. KOH / ethanol / 1 h / Heating
3.1: oxalyl chloride; DMF / tetrahydrofuran / 1 h
4.1: diethyl ether; tetrahydrofuran
4.2: HCl / diethyl ether; tetrahydrofuran
View Scheme
参考文献
Kaila, Neelu; Janz, Kristin; Huang, Adrian; Moretto, Alessandro; DeBernardo, Silvano; Bedard, Patricia W.; Tam, Steve; Clerin, Valerie; Keith Jr., James C.; Tsao, Desiree H.H.; Sushkova, Natalia; Shaw, Gray D.; Camphausen, Raymond T.; Schaub, Robert G.; Wang, Qin
Journal of Medicinal Chemistry, 2007 , vol. 50, # 1 p. 40 - 64