4-甲氧基-2-甲基-联苯合成路线 （共 109 条）
反应条件
1: 94 percent / pyridine / 12 h / 20 °C
2: 40 percent / Pd(dba)2; 2-dicyclohexylphosphinobiphenyl; TBAF / dioxane / 6 h / Heating
View Scheme
参考文献
Seganish, W. Michael; DeShong, Philip
Journal of Organic Chemistry, 2004 , vol. 69, # 4 p. 1137 - 1143
反应条件
1.1: 3.5 g / diethyl ether / 12 h / Heating
2.1: tetrabutylammonium fluoride trihydrate / tetrahydrofuran; H2O / 1 h / 20 °C
2.2: 92 percent / 2-dicyclohexylphosphino-2',4',6'-triisopropylbiphenyl / [(η3-C3H5)PdCl]2 / tetrahydrofuran; H2O / 4 h / 80 °C
View Scheme
参考文献
Sahoo, Akhila K.; Oda, Takuro; Nakao, Yoshiaki; Hiyama, Tamejiro
Advanced Synthesis and Catalysis, 2004 , vol. 346, # 13-15 p. 1715 - 1727
反应条件
1.1: 7.5 g / diethyl ether / 12 h / Heating
2.1: tetrabutylammonium fluoride trihydrate / tetrahydrofuran; H2O / 1 h / 20 °C
2.2: 93 percent / 2-dicyclohexylphosphino-2',4',6'-triisopropylbiphenyl / [(η3-C3H5)PdCl]2 / tetrahydrofuran; H2O / 4 h / 80 °C
View Scheme
参考文献
Sahoo, Akhila K.; Oda, Takuro; Nakao, Yoshiaki; Hiyama, Tamejiro
Advanced Synthesis and Catalysis, 2004 , vol. 346, # 13-15 p. 1715 - 1727
反应条件
3-benzyl-1-(2-hydroxy-2-phenylethyl)imidazolium chloride; water; palladium diacetate; sodium hydroxide
T=120°C; Hiyama coupling; 1 h; Microwave irradiation;
参考文献
Penafiel, Itziar; Pastor, Isidro M.; Yus, Miguel; Esteruelas, Miguel A.; Olivan, Montserrat; Onate, Enrique
European Journal of Organic Chemistry, 2011 , # 35 p. 7174 - 7181
反应条件
cesium hydroxide; water; 1,4-di(diphenylphosphino)-butane; bis(η3-allyl-μ-chloropalladium(II)) in 1,4-dioxane
T=90°C; 24 h; Product distribution; Further Variations:SolventsTemperaturesamount of water;
参考文献
Denmark, Scott E.; Ober, Michael H.
Advanced Synthesis and Catalysis, 2004 , vol. 346, # 13-15 p. 1703 - 1714
反应条件
C34H38Cl2N4Pd; caesium carbonate in 1,4-dioxane
T=100°C; Suzuki coupling; 25 h;
参考文献
Morgan, Brad P.; Galdamez, Gabriela A.; Gilliard Jr., Robert J.; Smith, Rhett C.
Dalton Transactions, 2009 , # 11 p. 2020 - 2028
反应条件
1.1: tert.-butyl lithium / diethyl ether; pentane / 0.5 h / -78 °C / |Inert atmosphere
1.2: -78 - 0 °C
2.1: tetrahydrofuran / 110 °C / |Inert atmosphere
View Scheme
参考文献
Minami, Hiroki; Wang, Xuan; Wang, Chao; Uchiyama, Masanobu
European Journal of Organic Chemistry, 2013 , # 35 p. 7891 - 7894
反应条件
potassium carbonate in water; isopropyl alcohol
Suzuki-Miyaura Coupling; 3 h; Green chemistry;
参考文献
Pandarus, Valerica; Gingras, Genevieve; Beland, Francois; Ciriminna, Rosaria; Pagliaro, Mario
Beilstein Journal of Organic Chemistry, 2014 , vol. 10, p. 897 - 901
参考文献
Khastagir; Bhattacharyya
Journal of the Indian Chemical Society, 1949 , vol. 26, p. 296,299
反应条件
1: HgBr2, HBr / CHCl3 / -20 °C
2: 66.5 percent Chromat. / AgBF4, pyridine, ethyl vinyl ether / CH2Cl2 / 24 h / Ambient temperature
3: Heating
View Scheme
参考文献
Bofinger, Klaus Rainer; Hanack, Michael
Chemische Berichte, 1985 , vol. 118, # 7 p. 2993 - 3003
