2-苄氧基甲基-4,5-二氯-3(2H)-吡嗪酮合成路线 （共 6 条）
反应条件
1: 4,5-dichloro-3-oxo-2,3-dihydro-pyridazine With sodium hydride in paraffin oil (nujol); N,N-dimethyl-formamide
T=0 - 20°C; 0.75 h; Inert atmosphere;
2: chloromethyl benzyl ether in paraffin oil (nujol); N,N-dimethyl-formamide
T=20°C;
参考文献
PIERRE FABRE MEDICAMENT; DUPONT-PASSELAIGUE, Elisabeth; MIALHE, Samuel; RIEU, Jean-Pierre; JUNQUERO, Didier; VALEILLE, Karine
Patent: WO2011/15629 A1, 2011 ;
Location in patent: Page/Page column 73 ;
WO 2011/015629 A1
参考文献
EGIS Gyogyszergyar
Patent: US5395934 A1, 1995 ;
反应条件
1: 93 percent / NaNO2 / H2O; dimethylformamide / 24 h / 80 - 90 °C
2: 80 percent / methanolic ammonia / dimethylformamide / 22 h / 130 °C / a sealed, glass-lined steel bomb
3: 85 percent / H2 / PtO2 / ethanol; ethyl acetate / 0.5 h / 1520 Torr / Ambient temperature
4: acetic anhydride / 1 h / Heating
View Scheme
参考文献
Gagnier; Halat; Otter
Journal of Heterocyclic Chemistry, 1984 , vol. 21, # 2 p. 481 - 489
反应条件
sodium nitrite in water; N,N-dimethyl-formamide
T=80 - 90°C; 24 h;
参考文献
Gagnier; Halat; Otter
Journal of Heterocyclic Chemistry, 1984 , vol. 21, # 2 p. 481 - 489
反应条件
1: 93 percent / NaNO2 / H2O; dimethylformamide / 24 h / 80 - 90 °C
2: 80 percent / methanolic ammonia / dimethylformamide / 22 h / 130 °C / a sealed, glass-lined steel bomb
View Scheme
参考文献
Gagnier; Halat; Otter
Journal of Heterocyclic Chemistry, 1984 , vol. 21, # 2 p. 481 - 489
反应条件
1: 93 percent / NaNO2 / H2O; dimethylformamide / 24 h / 80 - 90 °C
2: 80 percent / methanolic ammonia / dimethylformamide / 22 h / 130 °C / a sealed, glass-lined steel bomb
3: 85 percent / H2 / PtO2 / ethanol; ethyl acetate / 0.5 h / 1520 Torr / Ambient temperature
View Scheme
参考文献
Gagnier; Halat; Otter
Journal of Heterocyclic Chemistry, 1984 , vol. 21, # 2 p. 481 - 489
