1: 2-(1H-indol-3-yl)glyoxylic acid With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in tetrahydrofuran; N,N-dimethyl-formamide T=20°C; 0.0833333 h; Inert atmosphere; 2: piperidine in tetrahydrofuran; N,N-dimethyl-formamide Inert atmosphere;

acetone

1: diethyl ether 2: acetone View Scheme

1.1: sodium hydrogencarbonate 2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide; tetrahydrofuran / 0.08 h / 20 °C / |Inert atmosphere 2.2: |Inert atmosphere View Scheme