反应条件
1: n-propyl-magnesium bromide With copper(l) iodide in diethyl ether
T=-20°C; 0.5 h;
2: 2,5-dihydro-2-furanone With chloro-trimethyl-silane in diethyl ether
T=-40 - 20°C;
3: With ammonium chloride in diethyl ether
T=20°C;
参考文献
Kenda, Benoit M.; Matagne, Alain C.; Talaga, Patrice E.; Pasau, Patrick M.; Differding, Edmond; Lallemand, Benedicte I.; Frycia, Anne M.; Moureau, Florence G.; Klitgaard, Henrik V.; Gillard, Michel R.; Fuks, Bruno; Michel, Philippe
Journal of Medicinal Chemistry, 2004 , vol. 47, # 3 p. 530 - 549
