反式-2-已烯-1-醇合成路线 （共 129 条）
反应条件
2-hydroxy-1,3-isoindolinedione; Co(acetylacetonate)3; oxygen in acetonitrile T=65°C; 5 h;
参考文献
Tetrahedron Letters, , vol. 36, # 38 p. 6923 - 6926
反应条件
1: With cis-[Ru(2,9-Me2phen)2(OH2)2](PF6)2 in acetonitrile T=55°C; 0.5 h; 2: With dihydrogen peroxide in acetonitrile 12 h;
参考文献
Organic Letters, , vol. 7, # 22 p. 5039 - 5042
反应条件
1: 1-Hydroxy-2-trans-hexene With Celite; pyridinium chlorochromate in dichloromethane
T=20°C;
2: methyl (triphenylphosphoranylidene)acetate in dichloromethane
T=20°C; Wittig olefination; 24 h;
参考文献
Bressette, Andrew R.; Glover IV, Louis C.
Synlett, 2004 , # 4 p. 738 - 740
反应条件
palladium on magnesium oxide in trifluorotoluene
T=180°C; 4 h; AutoclaveInert atmosphere;
参考文献
Corma, Avelino; Rodenas, Tania; Sabater, Maria J.
Chemistry - A European Journal, 2010 , vol. 16, # 1 p. 254 - 260
反应条件
1: 1-Hydroxy-2-trans-hexene With [Rh(acac)2(CO)2]; C17H20NOP; toluene-4-sulfonic acid in benzene
T=55°C; 0.166667 h; Inert atmosphere;
2: carbon monoxide With hydrogen in benzene
T=55°C; P=2585.81 Torr; 16 h;
3: With sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene in water; tert-butyl alcohol
Pinnick oxidation; 6 h; Inert atmosphere; regioselective reaction;
参考文献
Lightburn, Thomas E.; De Paolis, Omar A.; Cheng, Ka H.; Tan, Kian L.
Organic Letters, 2011 , vol. 13, # 10 p. 2686 - 2689
反应条件
hydrogenchloride; oxygen; copper dichloride; palladium dichloride in tetrahydrofuran
P=760 Torr; Ambient temperature;
参考文献
Alper, Howard; Leonard, Daniele
Tetrahedron Letters, 1985 , vol. 26, # 46 p. 5639 - 5642
反应条件
1: 1-Hydroxy-2-trans-hexene With chloro-trimethyl-silane; sodium iodide in acetonitrile
T=20°C; 0.5 h;
2: potassium cyanide in acetonitrile
16 h;
参考文献
Trenner, Johanna; Depken, Christian; Weber, Thomas; Breder, Alexander
Angewandte Chemie - International Edition, 2013 , vol. 52, # 34 p. 8952 - 8956
Angew. Chem., 2013 , vol. 125, # 34 p. 9121 - 9125,5
反应条件
1: 75 percent / Me3SiCl, NaI, H2O / acetonitrile / 0.5 h / Ambient temperature
2: 92 percent / acetonitrile / 2 h / Heating
View Scheme
参考文献
Kanai, Takaya; Kanagawa, Yoshinori; Ishii, Yasutaka
Journal of Organic Chemistry, 1990 , vol. 55, # 10 p. 3274 - 3277
反应条件
chloro-trimethyl-silane; water; sodium iodide
1.) CH3CN, 0.5 h, room temperature, 2.) 2 h, reflux; Yield given. Multistep reaction;
参考文献
Kanai, Takaya; Kanagawa, Yoshinori; Ishii, Yasutaka
Journal of Organic Chemistry, 1990 , vol. 55, # 10 p. 3274 - 3277
反应条件
tetrabutylammomium bromide; chlorodimethyl(phenylthio)chloride methanaminium in dichloromethane
T=20°C; Bromination;
参考文献
Gomez; Gellibert; Wagner; Mioskowski
Tetrahedron Letters, 2000 , vol. 41, # 32 p. 6049 - 6052
