1: 2-methoxy-phenylmagnesium bromide With tris-(dibenzylideneacetone)dipalladium(0); pinacol phosphonate in tetrahydrofuran T=20°C; Kumada-Corriu cross-coupling reaction; 0.0833333 h; Inert atmosphere; 2: cyclohept-1-en-1-yl 4-methylbenzenesulfonate in tetrahydrofuran T=60°C; Kumada-Corriu cross-coupling reaction; 22 h; Inert atmosphere; chemoselective reaction;

1: pyridine / dichloromethane / 5 h / 25 °C / |Inert atmosphere 2: Pd(F6-acac)2; 1,3-bis-(diphenylphosphino)propane; lithium carbonate; 1,2-dimethoxy-benzene / 72 h / 120 °C / |Inert atmosphere View Scheme

1,2-dimethoxy-benzene; Pd(F6-acac)2; 1,3-bis-(diphenylphosphino)propane; lithium carbonate T=120°C; Heck Reaction; 72 h; Inert atmosphere; Overall yield = 87 percent; Overall yield = 88 mg;

(i), (ii) aq. oxalic acid; Multistep reaction;