5-[2-(三氟甲基)苯基]-2-糠酸合成路线 （共 3 条）
反应条件
1: 2-aminotrifluoromethylbenzene With hydrogenchloride; sodium nitrite in water T=0°C; 0.333333 h; 2: furan-2-carboxylic acid With copper dichloride in water; acetone T=20°C; 24 h;
参考文献
Huguet, Florian; Melet, Armelle; Alves de Sousa, Rodolphe; Lieutaud, Aurelie; Chevalier, Jacqueline; Maigre, Laure; Deschamps, Patrick; Tomas, Alain; Leulliot, Nicolas; Pages, Jean-Marie; Artaud, Isabelle
ChemMedChem, 2012 , vol. 7, # 6 p. 1020 - 1030
反应条件
potassium hydroxide in ethanol 0.5 h; Reflux;
参考文献
Gorak; Obushak; Matiichuk; Lytvyn
Russian Journal of Organic Chemistry, 2009 , vol. 45, # 4 p. 541 - 550
反应条件
1: SOCl2 / DMF / 0.67 h / Heating
2: 86 percent / triethylamine / CHCl3 / 1.) -5 to 0 deg C, 30 min; 2.) r.t., 1 h
3: PCl5 / benzene / 0.25 h / 75 °C
4: sodium azide / dimethylformamide / 0.5 h
5: 92 percent / 1.) 3M KOH, 2.) 15percent HCl / methanol; H2O / 1 h / Heating
View Scheme
参考文献
Janda; Voticky; Svetlik; et al.
Collection of Czechoslovak Chemical Communications, 1984 , vol. 49, # 6 p. 1505 - 1514
