2,5-二甲氧基苯甲醛合成路线 （共 179 条）
反应条件
in acetic acid
T=20°C; Bromination; 72 h;
参考文献
Sardessai, Manik S.; Abramson, Hanley N.
Organic Preparations and Procedures International, 1991 , vol. 23, # 4 p. 419 - 424
参考文献
Sato, Kenichiro; Asao, Naoki; Yamamoto, Yoshinori
Journal of Organic Chemistry, 2005 , vol. 70, # 22 p. 8977 - 8981
参考文献
Rubenstein
Journal of the Chemical Society, 1925 , vol. 127, p. 2003
反应条件
potassium tert-butylate in N,N-dimethyl-formamide
T=100°C; 6 h;
参考文献
Berner; Klein; Nazeeruddin; De Angelis, Filippo; Castellani; Bugnon; Scopelliti; Zuppiroli; Graetzel
Journal of Materials Chemistry, 2006 , vol. 16, # 46 p. 4468 - 4474
反应条件
nitric acid in acetic acid
T=10 - 15°C; 1 h; Yield given. Yields of byproduct given;
参考文献
Cotelle, Philippe; Catteau, Jeanpierre
Synthetic Communications, 1996 , vol. 26, # 22 p. 4105 - 4112
反应条件
nitric acid
Ambient temperature;
参考文献
Shaikh; Johnson; Grollman
Journal of Medicinal Chemistry, 1986 , vol. 29, # 8 p. 1329 - 1340
反应条件
nitric acid; acetic acid in diethyl ether
30 h; Ambient temperature;
参考文献
Del Mar Blanco; Avendano; Cabezas; Menendez
Synthetic Communications, 1993 , vol. 23, # 10 p. 1351 - 1356
参考文献
Rubenstein
Journal of the Chemical Society, 1925 , vol. 127, p. 2003
反应条件
1: toluene / 4 h / |Reflux; |Dean-Stark
2: sodium tetrahydroborate / methanol / 3 h / 20 °C
3: sodium carbonate / dichloromethane / 6 h / 20 °C
4: hydrogenchloride / 1,4-dioxane / 7 h / |Inert atmosphere; |Reflux
5: hydrogenchloride; trichloroisocyanuric acid / 48 h / 0 - 20 °C
View Scheme
参考文献
Naciuk, Fabricio F.; Milan, Julio C.; Andreao, Almir; Miranda, Paulo C.M.L.
Journal of Organic Chemistry, 2013 , vol. 78, # 10 p. 5026 - 5030
反应条件
1.1: HNO3 / CH2Cl2 / 1 h / 0 - 5 °C
2.1: AcOH; NaOAc / 5 h / Heating
3.1: H2; HCOONH4 / Pd/C / ethanol / 0.5 h / Heating
4.1: 82 percent / NaH / tetrahydrofuran / 4 h / 20 °C
5.1: n-BuLi / tetrahydrofuran; hexane / 2 h / -78 °C
5.2: 70 percent / tetrahydrofuran / -78 - 20 °C
6.1: 76 percent / ceric (IV) ammonium nitrate / acetonitrile; H2O / 0.5 h / 20 °C
View Scheme
参考文献
Mahboobi, Siavosh; Sellmer, Andreas; Eichhorn, Emerich; Beckers, Thomas; Fiebig, Heinz-Herbert; Kelter, Gerhard
European Journal of Medicinal Chemistry, 2005 , vol. 40, # 1 p. 85 - 92
