1.1: acetic acid / 0.5 h / 0 °C
1.2: 0 - 20 °C
2.1: n-butyllithium / tetrahydrofuran; cyclohexane / 0.25 h / -60 °C
2.2: 1 h
3.1: sodium amide / 2 h / 20 °C
4.1: borane-THF / tetrahydrofuran / 12 h / 20 °C
4.2: 1 h
5.1: triethylamine / dichloromethane / 20 °C
6.1: lithium aluminium tetrahydride / tetrahydrofuran / 1.5 h / |Reflux
7.1: ethanol / |Resolution of racemate
8.1: sodium hydroxide / ethyl acetate
9.1: potassium carbonate / acetone / 18 h / |Reflux
View Scheme
参考文献
LES LABORATOIRES SERVIER; CARRANZA, Maria Del Pilar; GARCIA ARANDA, Maria Isabel; GONZALEZ, José Lorenzo; SANCHEZ, Frédéric
Patent: US2014/163220 A1, 2014 ;
Barbour, Leonard J.; Steed, Jonathan W.; Atwood, Jerry L.
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1995 , # 4 p. 857 - 860
Carre; Libermann
Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1934 , vol. 199, p. 791
Bulletin de la Societe Chimique de France, 1935 , vol. <5> 2, p. 291,293
Full Text Show Details
Lindsey
Journal of the Chemical Society, 1965 , p. 1685,1690
Carre; Libermann
Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1934 , vol. 199, p. 791
Bulletin de la Societe Chimique de France, 1935 , vol. <5> 2, p. 291,293
Full Text Show Details
Lindsey
Journal of the Chemical Society, 1965 , p. 1685,1690
