3,4-二甲氧基苯甲酸合成路线 （共 364 条）
反应条件
pyridine; thionyl chloride in benzene
参考文献
Kureha Kagaku Kogyo Kabushiki Kaisha
Patent: US4409240 A1, 1983 ;
参考文献
Daiichi Seiyaku Co., Ltd.
Patent: US4239903 A1, 1980 ;
参考文献
Meyer,H.
Monatshefte fuer Chemie, 1901 , vol. 22, p. 418
Monatshefte fuer Chemie, 1906 , vol. 27, p. 43
参考文献
v. Kostanecki; Tambor
Chemische Berichte, 1906 , vol. 39, p. 4023
反应条件
methanesulfonyl chloride; triethylamine in tetrahydrofuran T=0°C;
参考文献
Daskiewicz, Jean-Baptiste; Depeint, Flore; Viornery, Lionel; Bayet, Christine; Comte-Sarrazin, Geraldine; Comte, Gilles; Gee, Jennifer M.; Johnson, Ian T.; Ndjoko, Karine; Hostettmann, Kurt; Barron, Denis
Journal of Medicinal Chemistry, 2005 , vol. 48, # 8 p. 2790 - 2804
参考文献
Popp, Frank D.; Duarte, Frederick F.; Uff, Barrie C.
Journal of Heterocyclic Chemistry, 1987 , vol. 24, p. 1353 - 1355
反应条件
1: (COCl)2; DMF / CH2Cl2 2: diethyl ether / 0 °C 3: aq. Ag2O / dioxane View Scheme
参考文献
Young, Jonathan R.; Huang, Song X.; Chen, Irene; Walsh, Thomas F.; DeVita, Robert J.; Wyvratt Jr., Matthew J.; Goulet, Mark T.; Ren, Ning; Lo, Jane; Yang, Yi Tien; Yudkovitz, Joel B.; Cheng, Kang; Smith, Roy G.
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 15 p. 1723 - 1727
反应条件
1: sulfuric acid / Reflux 2: nitric acid; acetic acid / 0 - 5 °C 3: 10 palladium on activated charcoal; hydrogen 4: 160 - 170 °C 5: methanesulfonic acid; [35S]-L-(-)-Methionine / 120 °C 6: pyridine; 4-(N,N-dimethlyamino)pyridine / 100 °C 7: trichlorophosphate / toluene / Reflux 8: pyridine / isopropyl alcohol / Reflux View Scheme
参考文献
Chen, Yurong; Feng, Man; Li, Shilei; Xu, Jingli; Ning, Hongyu; He, Yong; Wang, Xiao; Ding, Rui; Qi, Chuanmin
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 14 p. 4745 - 4749
反应条件
1: bromine; hydrogenchloride / water / 3 h / 20 - 30 °C 2: sodium carbonate; copper(II) sulfate; pyridine; water / 1 h / 80 - 100 °C 3: sulfuric acid / toluene / 2.5 h / |Inert atmosphere; |Reflux View Scheme
参考文献
Zeria Pharmaceutical Co., LTD; Nakao, Ryu
Patent: US2013/253222 A1, 2013 ;
反应条件
1: LiAlH4 / tetrahydrofuran / 0 °C / r.t., overnight 2: PPh3; CBr4 / CH2Cl2 / 2 h / reflux View Scheme
参考文献
Nishiwaki, Hisashi; Nakagawa, Yoshiaki; Takeda, David Y.; Okazawa, Atsushi; Akamatsu, Miki; Miyagawa, Hisashi; Ueno, Tamio; Nishimura, Keiichiro
Pest Management Science, 2000 , vol. 56, # 10 p. 875 - 881
