3,4-二甲氧基苯乙酸合成路线 （共 159 条）
反应条件
manganese triacetate in acetic acid 0.333333 h; Heating;
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 44, # 12 p. 2218 - 2222
反应条件
PPA T=90 - 95°C; 0.5 h;
参考文献
Yamato, Takehiko; Inoue, Hisataka; Fukumoto, Maki; Tashiro, Masashi
Organic Preparations and Procedures International, 1995 , vol. 27, # 4 p. 495 - 498
反应条件
PPA T=90°C; 0.333333 h;
参考文献
Sladkov, V. I.; Medzhitov, D. R.; Khokhlov, V. A.; Suvorov, N. N.
Journal of Organic Chemistry USSR (English Translation), 1989 , vol. 25, # 4.2 p. 774 - 779
Zhurnal Organicheskoi Khimii, 1989 , vol. 25, # 4 p. 862 - 868
反应条件
PPA in dichloromethane T=80°C; 72 h;
参考文献
Venkov, Atanas P.; Ivanov, Ilian I.
Tetrahedron, 1996 , vol. 52, # 37 p. 12299 - 12308
反应条件
boron trifluoride diethyl etherate T=80°C; 2 h; Inert atmosphere;
参考文献
Ng, Lean-Teik; Ko, Horng-Huey; Lu, Tzy-Ming
Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 13 p. 4360 - 4366
反应条件
Oxonetrade;; potassium chloride in water; acetonitrile T=20°C; 1 h;
参考文献
GENENTECH, INC.; CURIS, INC.
Patent: WO2008/137408 A1, 2008 ;
Location in patent: Page/Page column 40 ;
WO 2008/137408 A1
反应条件
1: LiAlH4 2: benzene; SOCl2 View Scheme
参考文献
Barash; Osbond
Journal of the Chemical Society, 1959 , p. 2157,2163
反应条件
Neutral lead acetate
参考文献
Kametani et al.
Yakugaku Kenkyu, 1958 , vol. 30, p. 185,191
Chem.Abstr., 1960 , p. 1517
反应条件
1: 92 percent / 2 h / 190 - 210 °C 2: phosphoryl chloride / toluene / 3 h / Heating 3: 71 percent / sodium borohydride / 19 h / Ambient temperature 4: 51 percent / benzene / 48 h / Heating View Scheme
参考文献
Stenlake; Waigh; Dewar; et al.
European Journal of Medicinal Chemistry, 1981 , vol. 16, # 6 p. 515 - 524
反应条件
1: 81 percent / thionyl chloride / CH2Cl2 / 1 h / Heating 2: triethylamine / CH2Cl2 / 1 h / Ambient temperature 3: 75 percent / glacial acetic acid, conc. HCl / 17 h / Ambient temperature 4: 1.) potassium tert-butoxide / 1.) DMSO, RT, 30 min, 2.) RT, 30 min View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 33, # 5 p. 1496 - 1504
