1-苯基-1,3-丁二酮合成路线 （共 471 条）
参考文献
Claisen
Chemische Berichte, 1926 , vol. 59, p. 151
反应条件
1: 1.) NaNO2; 2.) zinc dust, sodium acetate / 2.) 60 deg C, 1 h, reflux, 2 h 2: 70 percent / NaBH4, BF3 etherate / tetrahydrofuran / 4 h / Ambient temperature View Scheme
参考文献
Fujii, Hiroshi; Yoshimura, Tetsuhiko; Kamada, Hitoshi
Tetrahedron Letters, 1997 , vol. 38, # 8 p. 1427 - 1430
反应条件
1: 1-phenylbutane-1,3-dione With potassium carbonate in N,N-dimethyl-formamide T=0°C; 0.5 h; 2: carbon disulfide in N,N-dimethyl-formamide T=0°C; 1 h; 3: ethyl bromide in N,N-dimethyl-formamide T=0 - 20°C;
参考文献
Bi, Xihe; Dong, Dewen; Liu, Qun; Pan, Wei; Zhao, Lei; Li, Bing
Journal of the American Chemical Society, 2005 , vol. 127, # 13 p. 4578 - 4579
反应条件
1: carbon disulfide; 1-phenylbutane-1,3-dione With tetrabutylammomium bromide; potassium carbonate in water T=20°C; 1 h; 2: Et-X, X = Hal in water T=20°C; 8.25 h; Further stages.;
参考文献
Fu, Zhenqian; Wang, Mang; Ma, Yuhui; Liu, Qun; Liu, Jun
Journal of Organic Chemistry, 2008 , vol. 73, # 19 p. 7625 - 7630
反应条件
titanium tetrachloride; zinc in tetrahydrofuran 1) room temperature, 3 h, 2) reflux, 40 h;
参考文献
Gao, Ju; Hu, Ming-yang; Chen, Jian-xie; Yuan, Su; Chen, Wei-xing
Tetrahedron Letters, 1993 , vol. 34, # 10 p. 1617 - 1620
反应条件
1: 1-phenylbutane-1,3-dione With piperidine; pyridine; ferrocenecarboxaldehyde; acetic acid in benzene Knoevenagel condensation; 12 h; Reflux; 2: methylhydrazine in ethanol T=20°C; Inert atmosphere;
参考文献
Klimova, Elena I.; Vazquez Lopez, Eduardo A.; Martinez Mendoza, Juan M.; Ramirez, Lena Ruiz; Alamo, Marcos Flores; Backinowsky, Leon V.
Journal of Heterocyclic Chemistry, 2009 , vol. 46, # 3 p. 484 - 491
反应条件
sodium methylate in methanol T=0 - 25°C; 3 h; Product distribution / selectivity;
参考文献
LABORATORIOS ALMIRALL, S.A.
Patent: WO2008/107064 A1, 2008 ;
Location in patent: Page/Page column 6;7 ;
反应条件
1-methyl-piperidine; copper diacetate in chloroform T=60°C; 72 h; regioselective reaction;
参考文献
Trogu, Elena; Cecchi, Luca; De Sarlo, Francesco; Guideri, Luca; Ponticelli, Fabio; Machetti, Fabrizio
European Journal of Organic Chemistry, 2009 , # 34 p. 5971 - 5978
反应条件
sodium ethanolate in ethanol
参考文献
Giovannoni, Maria Paola; Vergelli, Claudia; Ghelardini, Carla; Galeotti, Nicoletta; Bartolini, Alessandro; Dal Piaz, Vittorio
Journal of Medicinal Chemistry, 2003 , vol. 46, # 6 p. 1055 - 1059
反应条件
1: 1-phenylbutane-1,3-dione With piperidine; pyridine; ferrocenecarboxaldehyde; acetic acid in benzene Knoevenagel condensation; 12 h; Reflux; 2: methylhydrazine in ethanol T=20°C; Inert atmosphere;
参考文献
Klimova, Elena I.; Vazquez Lopez, Eduardo A.; Martinez Mendoza, Juan M.; Ramirez, Lena Ruiz; Alamo, Marcos Flores; Backinowsky, Leon V.
Journal of Heterocyclic Chemistry, 2009 , vol. 46, # 3 p. 484 - 491
