1-苯基-1,3-丁二酮合成路线 （共 471 条）
参考文献
Claisen
Chemische Berichte, 1926 , vol. 59, p. 151
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v. Auwers
Chemische Berichte, 1912 , vol. 45, p. 996
Justus Liebigs Annalen der Chemie, 1918 , vol. 415, p. 227
反应条件
1: 1.) LDA, 2.) 10percent HCl / tetrahydrofuran
2: 86.1 percent
View Scheme
参考文献
Ohta, Shunsaku; Tsujimura, Atsuhiko; Okamoto, Masao
Chemical & Pharmaceutical Bulletin, 1981 , vol. 29, # 10 p. 2762 - 2768
参考文献
Ohta, Shunsaku; Tsujimura, Atsuhiko; Okamoto, Masao
Chemical & Pharmaceutical Bulletin, 1981 , vol. 29, # 10 p. 2762 - 2768
反应条件
sodium ethanolate; toluene-4-sulfonic acid in ethanol; benzene
参考文献
Gruppo Lepetit S.p.A.
Patent: US4022766 A1, 1977 ;
参考文献
Nishiwaki, Nagatoshi; Nishimoto, Toyosato; Tamura, Mina; Ariga, Masahiro
Synlett, 2006 , # 9 p. 1437 - 1439
反应条件
1,8-diazabicyclo[5.4.0]undec-7-ene in tert-butyl alcohol
0.5 h; Heating;
参考文献
Marquet, Jorge; Moreno-Manas, Marcial; Pacheco, Pedro; Prat, Maria; Katritzky, Alan R.; Brycki, Bogumil
Tetrahedron, 1990 , vol. 46, # 15 p. 5333 - 5346
反应条件
1: 1-phenylbutane-1,3-dione With tetra-(n-butyl)ammonium iodide; copper; potassium carbonate in toluene
3 h; Heating;
2: n-bromopentane in toluene
T=50°C; 43 h; Further stages.;
参考文献
Taber; Jiang
Journal of Organic Chemistry, 2001 , vol. 66, # 5 p. 1876 - 1884
反应条件
(i) NaH, THF, (ii) nBuLi, hexane, (iii) CuCl, I2, Et2O; Multistep reaction;
参考文献
Hampton,K.G.; Christie,J.J.
Journal of Organic Chemistry, 1975 , vol. 40, p. 3887 - 3889
反应条件
1: oxalic acid / benzene / Heating
2: diphosphorus pentaoxide / ethanol / Heating
View Scheme
参考文献
Horiguchi, Emi; Funabiki, Kazumasa; Matsui, Masaki
Bulletin of the Chemical Society of Japan, 2005 , vol. 78, # 2 p. 316 - 322
反应条件
sodium ethanolate; toluene-4-sulfonic acid in ethanol; benzene
参考文献
Gruppo Lepetit S.p.A.
Patent: US4402970 A1, 1983 ;
