反应条件
1.1: pyridinium p-toluenesulfonate / cyclohexane / 4 h / |Reflux; |Inert atmosphere; |Dean-Stark
2.1: diethylzinc / 1,2-dichloro-ethane / 0.42 h / -7 - 0 °C / |Inert atmosphere; |Enzymatic reaction
2.2: 2.5 h / -12 - 25 °C / |Inert atmosphere
3.1: potassium carbonate; trimethylsilyl iodide / dichloromethane / 1 h / -8 - -6 °C / |Inert atmosphere
4.1: lithium hexamethyldisilazane; n-butyllithium / hexane; tetrahydrofuran / 0.5 h / -15 - -7 °C / |Inert atmosphere
4.2: 3 h / -15 - 0 °C / |Inert atmosphere
5.1: sulfuric acid / water; 1,4-dioxane / 18 h / |Inert atmosphere; |Reflux
6.1: 3,3-dimethyldioxirane / acetone / 1 h / 25 °C / |Inert atmosphere
7.1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane; toluene / 1 h / 25 °C / |Inert atmosphere
7.2: 18 h / -10 - 25 °C / |Inert atmosphere
View Scheme
参考文献
Sarabu, Ramakanth; Bizzarro, Fred T.; Corbett, Wendy L.; Dvorozniak, Mark T.; Geng, Wanping; Grippo, Joseph F.; Haynes, Nancy-Ellen; Hutchings, Stanley; Garofalo, Lisa; Guertin, Kevin R.; Hilliard, Darryl W.; Kabat, Marek; Kester, Robert F.; Ka, Wang; Liang, Zhenmin; Mahaney, Paige E.; Marcus, Linda; Matschinsky, Franz M.; Moore, David; Racha, Jagdish; Radinov, Roumen; Ren, Yi; Qi, Lida; Pignatello, Michael; Spence, Cheryl L.; Steele, Thomas; Tengi, John; Grimsby, Joseph
Journal of Medicinal Chemistry, 2012 , vol. 55, # 16 p. 7021 - 7036
