4,5-二氯-3-羟基哒嗪合成路线 （共 68 条）
反应条件
zinc(II) chloride; lead(IV) acetate 20 h; Heating; Product distribution; Further Variations:Reagents;
参考文献
Tetrahedron Letters, , vol. 45, # 48 p. 8781 - 8784
反应条件
trichlorophosphate in toluene
Chlorination; aromatization; 8 h; Heating;
参考文献
Kweon, Deok-Heon; Kang, Young-Jin; Chung, Hyun-A.; Park, Jung-Won; Lee, Woo Song; Yoon, Yong-Jin; Kim, Sung-Kyu; Shiro, Motoo
Journal of Heterocyclic Chemistry, 1999 , vol. 36, # 5 p. 1301 - 1306
反应条件
in N,N-dimethyl-formamide
Heating;
参考文献
Sotelo, Eddy; Ravina, Enrique
Synthetic Communications, 2002 , vol. 32, # 11 p. 1675 - 1680
反应条件
potassium carbonate
8 h; Heating;
参考文献
Cho, Su-Dong; Choi, Woo-Yong; Yoon, Yong-Jin
Journal of Heterocyclic Chemistry, 1996 , vol. 33, # 6 p. 1579 - 1582
反应条件
sodium ethanolate in ethanol; dichloromethane
T=80°C; 1 h;
参考文献
ASTEX TECHNOLOGY LIMITED
Patent: WO2006/3440 A1, 2006 ;
Location in patent: Page/Page column 162 ;
WO 2006/003440 A1
反应条件
sodium hydroxide in water; dimethyl sulfoxide
1 h; Heating;
参考文献
Okafor; Castle
Journal of Heterocyclic Chemistry, 1983 , vol. 20, # 1 p. 199 - 203
反应条件
sodium hydroxide in water; dimethyl sulfoxide
20 h; Heating;
参考文献
Okafor; Castle
Journal of Heterocyclic Chemistry, 1983 , vol. 20, # 1 p. 199 - 203
反应条件
sodium perchlorate; acetic acid
T=18 - 20°C; 2 h;
参考文献
Park, Yong-Dae; Kim, Jeum-Jong; Cho, Su-Dong; Lee, Sang-Gyeong; Falck, J. Russell; Yoon, Yong-Jin
Synthesis, 2005 , # 7 art. no. F15604SS, p. 1136 - 1140
反应条件
1: 4,5-dichloro-3-oxo-2,3-dihydro-pyridazine With sodium hydride in paraffin oil (nujol); N,N-dimethyl-formamide
T=0 - 20°C; 0.75 h; Inert atmosphere;
2: chloromethyl benzyl ether in paraffin oil (nujol); N,N-dimethyl-formamide
T=20°C;
参考文献
PIERRE FABRE MEDICAMENT; DUPONT-PASSELAIGUE, Elisabeth; MIALHE, Samuel; RIEU, Jean-Pierre; JUNQUERO, Didier; VALEILLE, Karine
Patent: WO2011/15629 A1, 2011 ;
Location in patent: Page/Page column 73 ;
WO 2011/015629 A1
反应条件
in isopropyl alcohol
2 h; Heating;
参考文献
Baranov; Tsypin; Malin; Laskin
Russian Journal of Applied Chemistry, 2004 , vol. 77, # 12 p. 1997 - 2000
