Alpha-甲基-1-哌啶乙醇合成路线 （共 12 条）
反应条件
1: benzene; thionyl chloride 2: phenyl lithium; diethyl ether; diethylamine View Scheme
参考文献
Bockmuehl; Ehrhart
Justus Liebigs Annalen der Chemie, 1949 , vol. 561, p. 52,76
反应条件
in water
T=0 - 20°C;
参考文献
Talybov; Abbasov; Mamedbeili; Kochetkov
Russian Journal of General Chemistry, 2010 , vol. 80, # 9 p. 1819 - 1824
反应条件
tert.-butylhydroperoxide; titanium(III) chloride in water
T=20°C;
参考文献
Spaccini, Raffaele; Ghilardi, Alessandra; Pastori, Nadia; Clerici, Angelo; Punta, Carlo; Porta, Ombretta
Tetrahedron, 2010 , vol. 66, # 11 p. 2044 - 2052
反应条件
ethanol; nickel
T=80 - 100°C; Hydrogenation;
参考文献
Bockmuehl; Ehrhart
Justus Liebigs Annalen der Chemie, 1949 , vol. 561, p. 52,76
Full Text Show Details
I.G. Farbenind.
Patent: DE547174 , 1930 ;
Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 17, p. 300
反应条件
potassium hydroxide; benzene
参考文献
Bandelin; Tuschhoff
Journal of the American Pharmaceutical Association (1912-1977), 1951 , vol. 40, p. 202
反应条件
hydrogenchloride; sodium tetrahydroborate; dihydrogen peroxide; sodium carbonate
1.) ether 2.) THF, reflux, 3h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Baboulene, Michel; Torregrosa, Jean-Luc; Speziale, Vincent; Lattes, Armand
Bulletin de la Societe Chimique de France, 1980 , vol. 2, # 11-12 p. 565 - 570
反应条件
sodium hydroxide in ethanol; water
T=70°C; var. of temp., conc. of NaOH, EA, ΔH(excit.), ΔS(excit.); Rate constantThermodynamic data;
参考文献
Stankovicova; Pokorna; Cizmarik
Pharmazie, 1999 , vol. 54, # 2 p. 152 - 153
反应条件
sodium hydroxide in ethanol; water
T=70°C; var. of temp., EA, ΔH(excit.), ΔS(excit.); Rate constantThermodynamic data;
参考文献
Stankovicova; Pokorna; Cizmarik
Pharmazie, 1999 , vol. 54, # 2 p. 152 - 153
反应条件
T=225°C; Hydrogenation;
参考文献
D'Ianni; Adkins
Journal of the American Chemical Society, 1939 , vol. 61, p. 1675,1676
反应条件
T=250°C; Hydrogenation;
参考文献
D'Ianni; Adkins
Journal of the American Chemical Society, 1939 , vol. 61, p. 1675,1676
