1.1: sodium methylate / methanol / 2 h / 0 - 5 °C / Large scale reaction 1.2: 4 h / 0 - 5 °C / Large scale reaction 2.1: hydrogen / 3 h / 55 °C / 7500.75 - 9000.9 Torr / Large scale reaction 3.1: formic acid / water / 22 h / 100 °C / Large scale reaction View Scheme
参考文献
Organic Process Research and Development, , vol. 15, # 6 p. 1392 - 1395
1: With tri-isobutyl aluminium in toluene T=20°C; 20 h; Reflux; 2: With water in toluene T=20 - 30°C; 3: With hydrogenchloride in water; toluene pH=5.0; Product distribution / selectivity;