1-[2-氨基-1-(4-甲氧基苯基)乙基]环己醇合成路线 （共 28 条）
反应条件
lithium aluminium tetrahydride; aluminium trichloride
参考文献
Chavan, Subhash P.; Khobragade, Dushant A.; Kamat, Subhash K.; Sivadasan, Latha; Balakrishnan, Kamalam; Ravindranathan; Gurjar, Mukund K.; Kalkote, Uttam R.
Tetrahedron Letters, 2004 , vol. 45, # 39 p. 7291 - 7295
反应条件
ammonia in water; ethyl acetate T=20°C; pH=9; 0.166667 h;
参考文献
HIKAL LIMITED; RAJENDER, Pershad Gupta; RAM, Shanker Singh; SAMBA, Laxminarayan Kattige; CHELLAIAH, Vijayakumar; VADDADI, Ganapathi
Patent: WO2010/100520 A1, 2010 ;
Location in patent: Page/Page column 12 ;
反应条件
hydrogenchloride; sodium borohydride in methanol; water; ethyl acetate
参考文献
Sepracor Inc.
Patent: US2004/106576 A1, 2004 ;
反应条件
1: 96 percent / sodium methoxide; tetrabutylammonium bromide / 15 h / 25 - 30 °C 2: H2; ammonia / Raney nickel / methanol / 3 h / 35 - 40 °C View Scheme
参考文献
Journal of Chemical Crystallography, , vol. 35, # 12 p. 957 - 963
反应条件
hydrogen; nickel in ethanol; ammonia T=20°C; P=3750.38 Torr; 7 h;
参考文献
EP1249447 A1, ;
Page 12 ;
反应条件
1: 1.) BuLi / 1.) THF, hexane, -70 deg C, 30 min, 2.) -65 deg C, 2 h 2: H2 / 5percent Rh/Al2O3 / ethanol; aq. NH3 View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 33, # 10 p. 2899 - 2905
反应条件
sodium hydroxide in methanol T=20°C; 0.25 h; Product distribution / selectivity;
参考文献
US2008/139849 A1, ;
Page/Page column 5 ;
反应条件
1: (4-methoxy-phenyl)-acetonitrile With sodium methylate in methanol T=-2 - 5°C; 2.75 - 3 h; 2: cyclohexanone in methanol T=-5 - 5°C; 5 - 6.5 h; Product distribution / selectivity;
参考文献
US2005/33088 A1, ;
Page/Page column 3 ;
反应条件
hydrogen in isopropyl alcohol T=45 - 55°C; P=7500.75 - 9000.9 Torr;
参考文献
Organic Process Research and Development, , vol. 15, # 6 p. 1392 - 1395
反应条件
1: 96 percent / aq. NaOH; Bu4NBr / methanol / 15 h / 25 - 30 °C 2: H2; NH3 / Raney nickel / methanol / 3 h / 35 - 40 °C / 7600 Torr View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 14, # 12 p. 3279 - 3281
