2-甲基吡咯-3-甲酸乙酯合成路线 （共 28 条）
参考文献
Benary
Chemische Berichte, 1911 , vol. 44, p. 490
Chemische Berichte, 1918 , vol. 51, p. 569
反应条件
acetic acid; paraformaldehyde
参考文献
Canadian Patents and Development Limited
Patent: US4070366 A1, 1978 ;
反应条件
1: 86 percent / NBS; benzoylperoxide / CCl4 / 0.25 h / Irradiation
2: 62 percent / 18-crown-6 / H2O; diethyl ether / 6 h / 50 °C
View Scheme
参考文献
Waly
Bollettino Chimico Farmaceutico, 2000 , vol. 139, # 5 p. 217 - 221
反应条件
potassium phosphate; N-methyl-2-(methylamino)ethylamine; copper(l) iodide in toluene
T=130°C; 2 h; Microwave;
参考文献
FibroGen, Inc.
Patent: US2008/4309 A1, 2008 ;
Location in patent: Page/Page column 22 ;
反应条件
N-bromosuccinmide in tetrahydrofuran
T=-78°C; 0.5 h;
参考文献
TAKEDA PHARMACEUTICAL COMPANY LIMITED
Patent: WO2006/36024 A1, 2006 ;
Location in patent: Page/Page column 147-148; 288 ;
反应条件
1: N,N-dimethyl-formamide With trichlorophosphate
T=0 - 20°C; 1 h;
2: 3-(ethoxycarbonyl)-2-methylpyrrole in N,N-dimethyl-formamide
T=0 - 20°C; 1 h;
3: With water; sodium hydroxide in N,N-dimethyl-formamide
T=60°C; pH=7 - 8; 2 h; Cooling with ice;
参考文献
Jin, Yun-Zhou; Fu, Da-Xu; Ma, Nan; Li, Zhan-Cheng; Liu, Quan-Hai; Xiao, Lin; Zhang, Rong-Hua
Molecules, 2011 , vol. 16, # 11 p. 9368 - 9385
反应条件
hydrogenchloride; diethyl ether
Erwaermen des entstandenen Imid-Hydrochlorids mit Wasser;
参考文献
Fischer; Schubert
Hoppe-Seyler's Zeitschrift fuer Physiologische Chemie, 1926 , vol. 155, p. 109
反应条件
Erwaermen des Reaktionsprodukts;
参考文献
Fischer; Schubert
Hoppe-Seyler's Zeitschrift fuer Physiologische Chemie, 1926 , vol. 155, p. 109
