反应条件
1: 1.) lithium diisopropylamide (LDA), 2.) HMPA, triethylamine / 1.) a) THF, -78 deg C, 1 h, b) from -78 deg C to 0 deg C, 5 min, 2.) -78 deg C, 1 h
2: 1.) methyllithium, 2) N-chlorosuccinimide / 1.) THF, RT, 1 h, 2.) -70 deg C, 1 h
3: 51 percent / lithium chloride / dimethylformamide / 23 h / 50 °C
View Scheme
参考文献
Denmark; Dappen; Sear; Jacobs
Journal of the American Chemical Society, 1990 , vol. 112, # 9 p. 3466 - 3474
