4-[[4-(4,4,5,5-四甲基-1,3,2-二氧硼杂环戊烷-2-基)苯基]甲基]哌嗪-1-羧酸叔丁酯合成路线 （共 5 条）
反应条件
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate in dimethyl sulfoxide T=90°C; 16 h; Inert atmosphere;
参考文献
ADVINUS THERAPEUTICS LIMITED; THAKKAR, Mahesh; KOUL, Summon; BHUNIYA, Debnath; MOOKHTIAR, Kasim; KURHADE, Santosh; MUNOT, Yogesh
Patent: WO2013/157022 A1, 2013 ;
Location in patent: Page/Page column 54-55 ;
反应条件
PS-NMM in tetrahydrofuran T=150°C; 0.75 h; Microwave irradiationin air;
参考文献
Spencer, John; Baltus, Christine B.; Patel, Hiren; Press, Neil J.; Callear, Samantha K.; Male, Louise; Coles, Simon J.
ACS Combinatorial Science, 2011 , vol. 13, # 1 p. 24 - 31
反应条件
1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 20 °C 2: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 16 h / 90 °C / |Inert atmosphere View Scheme
反应条件
1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 20 °C 2: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / dimethyl sulfoxide / 16 h / 90 °C / |Inert atmosphere View Scheme
反应条件
1: tetrabutylammomium bromide; palladium diacetate; potassium carbonate / water / 0.17 h / 150 °C / Microwave irradiation 2: trifluoroacetic acid / dichloromethane / 20 °C 3: polystyrene N-methylmorpholine / dichloromethane / 6 h / 20 °C 4: 10 palladium on activated charcoal; hydrogen / ethanol; ethyl acetate / 65 °C View Scheme
参考文献
Spencer, John; Baltus, Christine B.; Press, Neil J.; Harrington, Ross W.; Clegg, William
Tetrahedron Letters, 2011 , vol. 52, # 31 p. 3963 - 3968
