1: 1-[(S)-1-(4-fluorophenyl)ethyl]piperidin-2-one With n-butyllithium; diisopropylamine in tetrahydrofuran; cyclohexane; toluene T=-20°C; 1.76667 - 148 h; 2: 3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzaldehyde in tetrahydrofuran; cyclohexane; toluene T=-20°C; 1.66667 - 2.66667 h; 3: With acetic anhydride; sodium t-butanolate Product distribution / selectivity; more than 3 stages;

1: 1-[(S)-1-(4-fluorophenyl)ethyl]piperidin-2-one With lithium diisopropyl amide in tetrahydrofuran; cyclohexane T=-70°C; 1 h; 2: diethyl chlorophosphate in tetrahydrofuran; cyclohexane T=-70°C; 1 h; 3: 3-methoxy-4-(4-methyl-1H-imidazol-1-yl)benzaldehyde With lithium diisopropyl amide Product distribution / selectivity; more than 3 stages;