4-甲基-3-硝基苯甲腈合成路线 （共 38 条）
反应条件
1: sulfuric acid / Hydrolysis 2: phosphorus pentachloride View Scheme
参考文献
Soderman; Johnson
Journal of the American Chemical Society, 1925 , vol. 47, p. 1394
参考文献
Justus Liebigs Annalen der Chemie, , vol. 467, p. 171
Journal fuer Praktische Chemie (Leipzig), , vol. <2> 109, p. 221
Justus Liebigs Annalen der Chemie, , vol. 441, p. 248
参考文献
Chemische Berichte, , vol. 44, p. 1122
参考文献
Colonge,J.; von Arx,P.
Bulletin de la Societe Chimique de France, 1965 , p. 1858 - 1862
反应条件
1: 70 percent / methanol / 48 h / Ambient temperature 2: 63 percent / Zn / acetic acid / 0.25 h / Heating View Scheme
参考文献
Liebigs Annalen der Chemie, , # 3 p. 438 - 455
反应条件
hydrogenchloride; chloroform
参考文献
Creary, Xavier
Journal of Organic Chemistry, 1993 , vol. 58, # 27 p. 7700 - 7708
反应条件
1: 4-methyl-3-nitrobenzenecarbonitrile With DMF-dimethylacetale in N,N-dimethyl-formamide T=110°C; 3 h; 2: acetic acid With iron in ethanol; N,N-dimethyl-formamide T=60°C; 2 h; Heating / reflux;
参考文献
SOLVAY PHARMACEUTICALS B.V.
Patent: US2006/122189 A1, 2006 ;
Location in patent: Page/Page column 20 ;
US 20060122189 A1
反应条件
1: dimethylformamide / 15 h / Heating 2: 9.07 g / hydrogen / Pd/C / tetrahydrofuran / 0.5 h / 2585.74 Torr View Scheme
参考文献
Bentley, David J.; Slawin, Alexandra M. Z.; Moody, Christopher J.
Organic Letters, 2006 , vol. 8, # 10 p. 1975 - 1978
反应条件
methanol; potassium hydroxide; dihydrogen peroxide bei Siedetemperatur;
参考文献
Macovski; Georgescu
Chemische Berichte, 1943 , vol. 76, p. 358,364
反应条件
1: 88 percent / NaOEt / ethanol / 16 h / Ambient temperature
2: 36 percent / aq. AcOH, Zn / 1 h / 75 °C
3: 45 percent / 5 N aq. NaOH / ethanol / 3 h / Heating
View Scheme
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; COOK, Brian Nicholas; KOWALSKI, Jennifer A.; LI, Xiang; MARSHALL, Daniel Richard; SCHLYER, Sabine; SIBLEY, Robert; SMITH-KEENAN, Lana Louise; SOLEYMANZADEH, Fariba; SORCEK, Ronald John; YOUNG, Erick Richard Roush; ZHANG, Yunlong
Patent: WO2012/6203 A1, 2012 ;
WO 2012/006203 A1
