反式-2-苯基环丙烷-1-羧酸合成路线 （共 31 条）
反应条件
1: aqueous KOH 3: ethanolic NaOH View Scheme
参考文献
Journal of the American Chemical Society, , vol. 79, p. 401,405
反应条件
1: diethyl ether; Ag2O; MgSO4 3: ethanolic NaOH View Scheme
参考文献
Journal of the American Chemical Society, , vol. 79, p. 401,405
反应条件
2: ethanolic NaOH View Scheme
参考文献
Journal of the American Chemical Society, , vol. 79, p. 401,405
反应条件
1: carbon monoxide With potassium cyanide; Ni(CN)2*4H2O; CoCl2*6H2O; hydrogen; potassium hydroxide in toluene T=95°C; 2 h; 2: 1-(2,2-dibromocyclopropyl)benzene in toluene T=95°C; 48 h; optical yield given as percent de;
参考文献
Journal of Medicinal Chemistry, , vol. 54, # 4 p. 957 - 969
反应条件
1.1: N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide / water / 20 h / 20 °C 2.1: potassium cyanide; CoCl2*6H2O; Ni(CN)2*4H2O; hydrogen; potassium hydroxide / toluene / 2 h / 95 °C 2.2: 48 h / 95 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 54, # 4 p. 957 - 969
反应条件
1: lithium tert-butylate / dichloromethane / 20 - 25 °C / |Inert atmosphere 2: sodium hydride / dimethyl sulfoxide; tetrahydrofuran / 25 °C / |Inert atmosphere 3: lithium hydroxide hydrate; water / ethanol / 1 h / |Reflux View Scheme
参考文献
WO2013/26914 A1, ;
WO 2013/026914 A1
反应条件
hydrogenchloride 2 h; Heating;
参考文献
Journal of Organic Chemistry USSR (English Translation), , vol. 19, p. 1298 - 1301
Zhurnal Organicheskoi Khimii, , vol. 19, # 7 p. 1445 - 1448
反应条件
sodium hydroxide 15 h; Heating;
参考文献
Synthesis, , # 6 p. 469 - 470
反应条件
dihydrogen peroxide 5 h; chloroperoxidase from Caldaromyces fumago, citrate buffer pH=5.0; Mechanism;
参考文献
Journal of the American Chemical Society, , vol. 117, # 42 p. 10419 - 10424
反应条件
T=100°C; 4 h; different concentration of peracide; MechanismProduct distribution;
参考文献
Tetrahedron, , vol. 38, # 14 p. 2083 - 2088
