4-(三氟甲氧基)苯磺酰氯合成路线 （共 5 条）
反应条件
phenyl sulphuryl chloride; C43H43NO3PPdS; sodium carbonate in acetone T=60°C; 12 h; Inert atmosphereSealed tube;
参考文献
Debergh, J. Robb; Niljianskul, Nootaree; Buchwald, Stephen L.
Journal of the American Chemical Society, 2013 , vol. 135, # 29 p. 10638 - 10641
反应条件
anhydrous sodium hydrogen carbonate in sulfuric acid; water; ethyl acetate
参考文献
Mitsubishi Chemical Corporation
Patent: US5840716 A1, 1998 ;
反应条件
ammonium hydroxide in acetonitrile T=0 - 20°C; 1 h; Inert atmosphere;
参考文献
Patil, Vikas; Kale, Manoj; Raichurkar, Anandkumar; Bhaskar, Brahatheeswaran; Prahlad, Dwarakanath; Balganesh, Meenakshi; Nandan, Santosh; Shahul Hameed
Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 9 p. 2222 - 2225
反应条件
1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 °C / Inert atmosphere
2: hydrogenchloride / dichloromethane; 1,4-dioxane / 2 h / 20 °C
View Scheme
参考文献
CONVERGENCE PHARMACEUTICALS LIMITED; Heer, Jag Paul; Cridland, Andrew Peter; Norton, David
Patent: US2013/72499 A1, 2013 ;
反应条件
pyridine
T=60°C; 1 h;
参考文献
The Institute for Pharmaceutical Discovery LLC
Patent: US2004/248937 A1, 2004 ;
Location in patent: Page 30 ;
US 20040248937 A1
