1,2,3,4-四氢咔唑合成路线 （共 202 条）
反应条件
N-benzyl-N,N,N-trimethyl-ammonium chloride 2 h; Heating;
参考文献
Rajasekaran; Thampi
European Journal of Medicinal Chemistry, 2005 , vol. 40, # 12 p. 1359 - 1364
反应条件
1: benzyl-trimethyl-ammonium hydroxide 2: ethanolic NaOH-solution View Scheme
参考文献
Esteban-Calderon; Martinez-Ripoll; Garcia-Blanco; et al.
Canadian Journal of Chemistry, 1986 , vol. 64, # 9 p. 1829 - 1835
反应条件
1: 89 percent / 2,3-dichloro-5,6-dicyanobenzoquinone / tetrahydrofuran; H2O / 5.5 h / 0 - 20 °C 2: 89 percent / 10percent aq. NaOH / 2 h / 60 - 70 °C View Scheme
参考文献
Rodriguez, Jose Gonzalo; Valle, Celestina del; Esteban-Calderon, Carmen; Martinez-Ripoll, Martin
Journal of Chemical Crystallography, 1995 , vol. 25, # 5 p. 249 - 258
反应条件
1: 75 percent / ethanol; H2O / 12 h / Heating 2: 1.) tert-butyllithium / 1.) a) hexane, pentane, -78 deg C, b) RT, 16 h, 2.) a) THF, -78 deg C, b) RT View Scheme
参考文献
Katritzky, Alan R.; Rewcastle, Gordon W.; Vazquez de Miguel, Luis M.
Journal of Organic Chemistry, 1988 , vol. 53, # 4 p. 794 - 799
反应条件
1: 25 percent / m-chloroperbenzoic acid / CH2Cl2 / 0.83 h / -60 °C / further conditions 2: 24 percent / m-chloroperbenzoic acid / CH2Cl2 / 1 h / -60 °C View Scheme
参考文献
Hino, Tohru; Yamaguchi, Hitoshi; Matsuki, Kenji; Nakano, Kumiko; Sodeoka, Mikiko; Nakagawa, Masako
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1983 , # 1 p. 141 - 146
反应条件
1: concentrated sulfuric acid; potassium nitrate / -5 - -3 °C 2: iron powder; diluted hydrochloric acid View Scheme
参考文献
Perkin; Plant
Journal of the Chemical Society, 1921 , vol. 119, p. 1836
Journal of the Chemical Society, 1923 , vol. 123, p. 676
反应条件
1: 100 percent / H2SO4 / 30 h / Ambient temperature 2: 83 percent / N2H4*H2O / methanol / 1.5 h / Heating View Scheme
参考文献
Muminov, A.; Yudin, L. G.; Zinchenko, E. Ya.; Romanova, N. N.; Kost, A. N.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1985 , vol. 21, # 9 p. 1012 - 1015
Khimiya Geterotsiklicheskikh Soedinenii, 1985 , vol. 21, # 9 p. 1218 - 1221
反应条件
1: 80 percent / H5IO6 / tetrahydrofuran; H2O / 0 °C 2: 85 percent / NaBH4 / methanol / 0 °C View Scheme
参考文献
Di Fabio, Romano; Giovannini, Riccardo; Bertani, Barbara; Borriello, Manuela; Bozzoli, Andrea; Donati, Daniele; Falchi, Alessandro; Ghirlanda, Damiano; Leslie, Colin P.; Pecunioso, Angelo; Rumboldt, Giovanna; Spada, Simone
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 6 p. 1749 - 1752
反应条件
hydrogen fluoride; dihydrogen peroxide; SbF5 T=-20°C; 0.05 h;
参考文献
Berrier, Christian; Jacquesy, Jean-Claude; Jouannetaud, Marie-Paule; Renoux, Alain
Tetrahedron Letters, 1986 , vol. 27, # 38 p. 4565 - 4568
反应条件
2,3-dicyano-5,6-dichloro-p-benzoquinone in tetrahydrofuran; water T=0 - 20°C; 5.5 h;
参考文献
Journal of Chemical Crystallography, , vol. 25, # 5 p. 249 - 258
