4-氨基-2-氯嘧啶-5-甲腈合成路线 （共 11 条）
反应条件
ammonium hydroxide in 1,4-dioxane T=0 - 20°C; 2 h;
参考文献
US2013/53362 A1, ;
Paragraph 0723; 0724; 0725 ;
反应条件
hydrogenchloride 0.333333 h;
参考文献
Schmidt, Hans-Werner; Koitz, Gerald; Junek, Hans
Journal of Heterocyclic Chemistry, 1987 , vol. 24, p. 1305 - 1307
反应条件
1: 4-amino-2-chloro-pyrimidine-5-carbonitrile With sodium hydride in N,N-dimethyl-formamide T=20°C; 0.0833333 h; 2: 1,3-dichloro-2-isocyanatobenzene in N,N-dimethyl-formamide T=20°C; 1 h;
参考文献
BANYU PHARMACEUTICAL CO.,LTD.; BAMBA, Makoto; FURUYAMA, Hidetomo; SAKAMOTO, Toshihiro; SUNAMI, Satoshi; TAKAHASHI, Keiji; YAMAMOTO, Fuyuki; YOSHIZUMI, Takashi
Patent: WO2010/67886 A1, 2010 ;
Location in patent: Page/Page column 62 ;
WO 2010/067886 A1
参考文献
Schmidt, Hans-Werner; Koitz, Gerald; Junek, Hans
Journal of Heterocyclic Chemistry, 1987 , vol. 24, p. 1305 - 1307
参考文献
Schmidt, Hans-Werner; Koitz, Gerald; Junek, Hans
Journal of Heterocyclic Chemistry, 1987 , vol. 24, p. 1305 - 1307
反应条件
in methanol 0.5 h; Heating;
参考文献
Schmidt, Hans-Werner; Koitz, Gerald; Junek, Hans
Journal of Heterocyclic Chemistry, 1987 , vol. 24, p. 1305 - 1307
反应条件
potassium hydroxide 1.) DMSO, 15 min, 2.) 50 deg, 1 h; Yield given. Multistep reaction;
参考文献
Uray, Georg; Kriessmann, Ingo
Synthesis, 1984 , # 8 p. 679 - 681
反应条件
hydrogen; triethylamine; 5 percent palladium-carbon in methanol P=1551.4 Torr; 3.5 h; Ambient temperature;
参考文献
Schmidt, Hans-Werner; Koitz, Gerald; Junek, Hans
Journal of Heterocyclic Chemistry, 1987 , vol. 24, p. 1305 - 1307
反应条件
ammonia T=60°C; 0.333333 h;
参考文献
Schmidt, Hans-Werner; Koitz, Gerald; Junek, Hans
Journal of Heterocyclic Chemistry, 1987 , vol. 24, p. 1305 - 1307
反应条件
in acetone 0.166667 h; Heating;
参考文献
Schmidt, Hans-Werner; Koitz, Gerald; Junek, Hans
Journal of Heterocyclic Chemistry, 1987 , vol. 24, p. 1305 - 1307
