Fmoc-Alpha-甲基丙氨酸合成路线 (共 5 条)
反应条件
water; sodium carbonate in 1,4-dioxane 16 h;
参考文献
Lescrinier, Theo; Hendrix, Chris; Kerremans, Luc; Rozenski, Jef; Link, Andreas; Samyn, Bart; Van Aerschot, Arthur; Lescrinier, Eveline; Eritja, Ramon; Van Beeumen, Jozef; Herdewijn, Piet
Chemistry - A European Journal, 1998 , vol. 4, # 3 p. 425 - 433
反应条件
hydrogenchloride; zinc in water; acetonitrile
参考文献
Babu, Vommina V. Suresh; Ananda, Kuppanna
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 2001 , vol. 40, # 1 p. 70 - 74
反应条件
1: T=55°C; 1 h; 2: With N-ethyl-N,N-diisopropylamine T=20°C; 0.333333 h; Mechanism; Time;
参考文献
Journal of the American Chemical Society, , vol. 130, # 44 p. 14382 - 14383
反应条件
1: H-L-Lol-2-chlorotrityl resin; fmoc-L-Ile-OH With N-ethyl-N,N-diisopropylamine; HATU
1 h; solid phase reaction;
2: With piperidine in N,N-dimethyl-formamide
solid phase reaction;
3: octanoic acid; N-(9-fluorenylmethoxycarbonyl)glycine; N-Fmoc-L-leucine; Fmoc-(α-aminoisobutyric acid)
参考文献
De Zotti, Marta; Biondi, Barbara; Peggion, Cristina; Formaggio, Fernando; Park, Yoonkyung; Hahm, Kyung-Soo; Toniolo, Claudio
Organic and Biomolecular Chemistry, 2012 , vol. 10, # 6 p. 1285 - 1299
参考文献
Tice, Colin M.; Michelotti, Enrique L.; Mata, Ernesto G.; Nicolas, Ernesto; Garcia, Javier; Albericio, Fernando
Tetrahedron Letters, 2002 , vol. 43, # 42 p. 7491 - 7494