5-(1-哌啶基)-2-氨基吡啶合成路线 （共 4 条）
反应条件
hydrogen; nickel in tetrahydrofuran
P=2585.74 Torr; 4 h;
参考文献
Toogood, Peter L.; Harvey, Patricia J.; Repine, Joseph T.; Sheehan, Derek J.; VanderWel, Scott N.; Zhou, Hairong; Keller, Paul R.; McNamara, Dennis J.; Sherry, Debra; Zhu, Tong; Brodfuehrer, Joanne; Choi, Chung; Barvian, Mark R.; Fry, David W.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 7 p. 2388 - 2406
参考文献
Barvian, Mark; Booth, Richard John; Ouin III, John; Thomas Repine, Joseph; Sheehan, Derek J.; Toogood, Peter Laurence; Vanderwel, Scott Norman; Zhou, Hairong
Patent: US2003/149001 A1, 2003 ;
US 20030149001 A1
反应条件
1: 86 percent / tetra-n-butylammonium iodide; K2CO3 / dimethylsulfoxide / 4 h / 80 °C
2: 86 percent / H2 / Raney Nickel / tetrahydrofuran / 4 h / 2585.74 Torr
View Scheme
参考文献
Toogood, Peter L.; Harvey, Patricia J.; Repine, Joseph T.; Sheehan, Derek J.; VanderWel, Scott N.; Zhou, Hairong; Keller, Paul R.; McNamara, Dennis J.; Sherry, Debra; Zhu, Tong; Brodfuehrer, Joanne; Choi, Chung; Barvian, Mark R.; Fry, David W.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 7 p. 2388 - 2406
反应条件
1: 86 percent / tetra-n-butylammonium iodide; K2CO3 / dimethylsulfoxide / 4 h / 80 °C
2: 86 percent / H2 / Raney Nickel / tetrahydrofuran / 4 h / 2585.74 Torr
View Scheme
参考文献
Toogood, Peter L.; Harvey, Patricia J.; Repine, Joseph T.; Sheehan, Derek J.; VanderWel, Scott N.; Zhou, Hairong; Keller, Paul R.; McNamara, Dennis J.; Sherry, Debra; Zhu, Tong; Brodfuehrer, Joanne; Choi, Chung; Barvian, Mark R.; Fry, David W.
Journal of Medicinal Chemistry, 2005 , vol. 48, # 7 p. 2388 - 2406
