4-氯-1,2-苯二胺合成路线 （共 167 条）
反应条件
in N,N-dimethyl-formamide
Heating;
参考文献
Merchan; Garin; Melendez; Tejero
Synthesis, 1982 , vol. No. 12, p. 1066 - 1067
反应条件
sodium acetate; acetic anhydride in water
参考文献
BASF Aktiengesellschaft
Patent: US5714489 A1, 1998 ;
参考文献
Ullmann; Mauthner
Chemische Berichte, 1903 , vol. 36, p. 4032
反应条件
in ethanol
24 h; Reflux;
参考文献
Seillan, Claire; Brisset, Hugues; Siri, Olivier
Organic Letters, 2008 , vol. 10, # 18 p. 4013 - 4016
参考文献
Landquist
Journal of the Chemical Society, 1956 , p. 2551
参考文献
Qayyoom, M. A.; Hanumanthu, P.; Ratnam, C. V
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1982 , vol. 21, # 9 p. 883 - 884
反应条件
hydrogenchloride
Heating;
参考文献
Wilson; Hunt
Australian Journal of Chemistry, 1983 , vol. 36, # 11 p. 2317 - 2325
反应条件
1: 37 percent / methanol; H2O / 24 h / Ambient temperature
2: 82 percent / NaBH4 / ethanol / 2.5 h / Ambient temperature
View Scheme
参考文献
Jacobsen, E. Jon; TenBrink, Ruth E.; Stelzer, Lindsay S.; Belonga, Kenneth L.; Carter, Donald B.; Im, Haesook K.; Im, Wha Bin; Sethy, Vimala H.; Tang, Andy H.; VonVoigtlander, Philip F.; Petke, James D.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 1 p. 158 - 175
反应条件
1: 98 percent / 16 h / Heating
2: 74 percent / POCl3 / 16 h / Heating
3: 97 percent / hydrazine hydrate / ethanol / 16 h / 25 °C
View Scheme
参考文献
KALYPSYS, INC.; BORCHARDT, Allen; DAVIS, Robert; BEAUREGARD, Clay; BECKER, Daniel; GAMACHE, Daniel; NOBLE, Stewart, A.; HELLBERG, Mark, R.; KLIMKO, Peter, G.; ZHIHAI, Qui; PAYNE, Joseph, E.; YANNI, John
Patent: WO2011/112731 A2, 2011 ;
WO 2011/112731 A2
反应条件
1: 98 percent / 16 h / Heating
2: 74 percent / POCl3 / 16 h / Heating
3: 97 percent / hydrazine hydrate / ethanol / 16 h / 25 °C
4: 57 percent / 24 h / 100 °C
View Scheme
参考文献
Sarges, Reinhard; Howard, Harry R.; Browne, Ronald G.; Lebel, Lorraine A.; Seymour, Patricia A.; Koe, B. Kenneth
Journal of Medicinal Chemistry, 1990 , vol. 33, # 8 p. 2240 - 2254
