1,2,4,5-四甲基苯合成路线 (共 381 条)
反应条件
1: N-bromosuccinmide / acetonitrile / 8 h / 0 - 20 °C 2: magnesium / tetrahydrofuran / 14 h 3: N-bromosuccinmide / acetonitrile / 8 h / 0 - 20 °C View Scheme
参考文献
Mandal, Susovan; Parida, Keshaba Nanda; Samanta, Subhas; Moorthy, Jarugu Narasimha
Journal of Organic Chemistry, 2011 , vol. 76, # 18 p. 7406 - 7414
反应条件
sulfuric acid T=85°C; Erhitzen der gebildeten 1.2.3.4-Tetramethyl-benzol-sulfonsaeure-(5) mit wss. H2SO4 auf 145grad;
参考文献
Birch et al.
Journal of the American Chemical Society, 1949 , vol. 71, p. 1362,1366
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Smith; Cass
Journal of the American Chemical Society, 1932 , vol. 54, p. 1609,1611
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Smith
Org. Reactions, 1942 , vol. 1, p. 370,382
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Moyle; Smith
Journal of Organic Chemistry, 1937 , vol. 2, p. 112,116, 132
反应条件
aluminium trichloride in tetrachloromethane 1.) 5 deg C, 1 h; 2.) 25 deg C, 1 h;
参考文献
Andreou et al.
Tetrahedron, 1980 , vol. 36, p. 2101
反应条件
aluminium trichloride in carbon disulfide 1.) 25 deg C, 1 h; 2.) 50 deg C, 3 h;
参考文献
Andreou et al.
Tetrahedron, 1980 , vol. 36, p. 2101
反应条件
aluminium trichloride in carbon disulfide T=25°C; 1 h; other acetylation agent, other solvents, other conditions, further tetramethylbenzenes; Product distribution;
参考文献
Andreou et al.
Tetrahedron, 1980 , vol. 36, p. 2101
反应条件
T=26.9°C; Zusammensetzung des Gleichgewichtsgemisches;
参考文献
Hastings; Nicholson
Journal of Physical Chemistry, 1957 , vol. 61, p. 730,734
反应条件
aluminium trichloride
参考文献
Vitorovic-Todorovic, Maja D.; Eric-Nikolic, Aleksandra; Kolundzija, Branka; Hamel, Ernest; Ristic, Slavica; Juranic, Ivan O.; Drakulic, Branko J.
European Journal of Medicinal Chemistry, 2013 , vol. 62, p. 40 - 50
反应条件
water-d2 in various solvent(s) Heating;
参考文献
Lau, W.; Kochi, J. K.
Journal of the American Chemical Society, 1984 , vol. 106, # 23 p. 7100 - 7112
参考文献
Weis,C.D.
Journal of Organic Chemistry, 1963 , vol. 28, p. 74 - 78
反应条件
sodium chlorite; trichloroacetic acid in dichloromethane Chlorination; 1 h;
参考文献
Monatshefte fur Chemie, , vol. 130, # 12 p. 1493 - 1497