(S)-(-)-1,1,2-三苯基-1,2-丁二醇2-醋酸酯合成路线 （共 8 条）
反应条件
pyridine 12 h; Ambient temperature;
参考文献
Ewing; Harris; Bhat; Joullie
Tetrahedron, 1986 , vol. 42, # 9 p. 2421 - 2428
反应条件
1: bromobenzene; ethyl (S)-(+)-2-hydroxy-2-phenylacetate With magnesium in tetrahydrofuran Grignard reaction; 16 h; Heating; 2: acetyl chloride With pyridine in dichloromethane T=20°C; Acetylation; 20 h;
参考文献
Organic Preparations and Procedures International, , vol. 23, # 2 p. 173 - 180
反应条件
1: 1.) Mg, I2 / 1.) THF, reflux, 3 h; 2.) THF, reflux, 3-5 h 2: pyridine / CH2Cl2 / 2 h / Ambient temperature View Scheme
参考文献
Chemische Berichte, , vol. 121, p. 397 - 406
反应条件
1: conc. H2SO4 / 5 h / Heating 2: 1.) Mg, I2 / 1.) THF, reflux, 3 h; 2.) THF, reflux, 3-5 h 3: pyridine / CH2Cl2 / 2 h / Ambient temperature View Scheme
参考文献
Chemische Berichte, , vol. 121, p. 397 - 406
反应条件
1.1: lithium diisopropylamide / tetrahydrofuran / -78 - 0 °C 1.2: 51 percent / tetrahydrofuran / 2.58 h / -78 °C 2.1: hydrazine; KCN / methanol / 24 h / Heating View Scheme
参考文献
Macor, John E.; Mullen, George; Verhoest, Patrick; Sampognaro, Anthony; Shepardson, Bruce; Mack, Robert A.
Journal of Organic Chemistry, 2004 , vol. 69, # 19 p. 6493 - 6495
反应条件
Yield given. Multistep reaction;
参考文献
Tempkin, Orin; Abel, Stephan; Chen, Chung-Pin; Underwood, Russell; Prasad, Kapa; Chen, Kau-Ming; Repic, Oljan; Blacklock, Thomas J.
Tetrahedron, 1997 , vol. 53, # 31 p. 10659 - 10670
反应条件
multistep reaction, various reaction conditions; Product distribution;
参考文献
Wuts; Putt
Synthesis, 1989 , # 12 p. 951 - 953
反应条件
Yield given. Multistep reaction;
参考文献
Tempkin, Orin; Abel, Stephan; Chen, Chung-Pin; Underwood, Russell; Prasad, Kapa; Chen, Kau-Ming; Repic, Oljan; Blacklock, Thomas J.
Tetrahedron, 1997 , vol. 53, # 31 p. 10659 - 10670
