4-(5-甲基-1,2,4-噁二唑-3-基)苯甲酸合成路线 （共 7 条）
反应条件
1: in dichloromethane T=20°C; 2: With pyridine T=95°C; 48 h; 3: With hydrogenchloride; methanol; sodium hydroxide; water more than 3 stages;
参考文献
WO2006/8133 A2, ;
Page/Page column 25 ;
WO 2006/008133 A2
反应条件
sodium hydroxide in methanol T=20°C; 16 h;
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 49, # 3 p. 268 - 277
反应条件
1: 83 percent / H2NOH*HCl; NaHCO3 / methanol / 3 h / Heating 2: 87 percent / CH2Cl2 / 9 h / 80 °C 3: 2 N aq. NaOH / methanol / 16 h / 20 °C View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 49, # 3 p. 268 - 277
反应条件
1: 87 percent / CH2Cl2 / 9 h / 80 °C 2: 2 N aq. NaOH / methanol / 16 h / 20 °C View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 49, # 3 p. 268 - 277
反应条件
1-nitroethane; ammonium acetate 96 h; Heating;
参考文献
Young, Thomas E.; Beidler, William Thomas
Journal of Organic Chemistry, 1985 , vol. 50, # 8 p. 1182 - 1186
参考文献
Chemische Berichte, , vol. 19, p. 1494
反应条件
thionyl chloride in N,N-dimethyl-formamide; toluene
参考文献
Merck Patent GmbH
Patent: US6492368 B1, 2002 ;
US 6492368 B1
