2-氯-1,3-噻唑-5-甲醛合成路线 （共 6 条）
反应条件
n-butyllithium in tetrahydrofuran; hexane; ethyl acetate; N,N-dimethyl-formamide; Petroleum ether
参考文献
Fotouhi, Nader; Gillespie, Paul; Guthrie, Robert William; Pietranico-Cole, Sherrie Lynn; Yun, Weiya
Patent: US2002/161237 A1, 2002 ;
反应条件
hydrogenchloride; n-butyllithium 1) hexane, THF, -78 deg C, 10 min., 2) THF, up to roomtemp., 2h; Yield given. Multistep reaction;
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 2 p. 329 - 331
反应条件
lithium hydroxide in tetrahydrofuran; water 20 h;
参考文献
Sawhney, Indu; Wilson, John R. H.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1990 , # 2 p. 329 - 331
反应条件
lithium hydroxide in tetrahydrofuran; water 20 h;
参考文献
Sawhney, Indu; Wilson, John R. H.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1990 , # 2 p. 329 - 331
反应条件
1: With sodium tetrahydroborate in ethanol 1 h; 2: With water; ammonium chloride in ethanol
参考文献
ELI LILLY AND COMPANY
Patent: WO2007/2181 A2, 2007 ;
Location in patent: Page/Page column 142-143 ;
WO 2007/002181 A2
反应条件
lithium hydroxide in tetrahydrofuran; water 20 h;
参考文献
Sawhney, Indu; Wilson, John R. H.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1990 , # 2 p. 329 - 331
