(R)-(+)-3-叔丁氧羰基-2,2-二甲基-4-噁唑烷羧酸甲合成路线 （共 16 条）
反应条件
lithium aluminium tetrahydride in tetrahydrofuran 0.166667 h; Ambient temperature;
参考文献
Dondoni; Perrone; Merino
Journal of Organic Chemistry, 1995 , vol. 60, # 24 p. 8074 - 8080
反应条件
diisobutylaluminium hydride T=-78°C;
参考文献
Yin, Jianming; Liu, Hanlan; Pidgeon, Charles
Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 2 p. 179 - 182
反应条件
1: With lithium hydroxide; water in tetrahydrofuran T=20°C; 48 h; 2: With hydrogenchloride in tetrahydrofuran; water pH=4;
参考文献
UCB PHARMA S.A.
Patent: WO2008/128919 A2, 2008 ;
Location in patent: Page/Page column 56 ;
WO 2008/128919 A2
反应条件
1: 85 percent / DIBAL / toluene / -78 °C 2: tetrahydrofuran / -78 - 0 °C 3: 80 percent / Swern oxidation View Scheme
参考文献
Nimkar; Menaldino; Merrill; Liotta
Tetrahedron Letters, 1988 , vol. 29, # 25 p. 3037 - 3040
反应条件
1: With diisobutylaluminium hydride in toluene
T=-78°C; 0.75 h;
2: With n-butyllithium; triphenylmethylphosphonium bromide in hexane; toluene
T=-78 - 20°C; 12 h;
参考文献
UNIVERSITY OF VIRGINIA PATENT FOUNDATION; SANTOS, Webster, L.; LYNCH, Kevin, R.; MACDONALD, Timothy, L.; KENNEDY, Andrew; KHAREL, Yugesh; RAJE, Mithun, Rajendra; HOUCK, Joseph
Patent: WO2013/119946 A1, 2013 ;
Location in patent: Paragraph 0236 ;
反应条件
diisobutylaluminium hydride
1.) toluene, -78 deg C, 1 h; 2.) THF, toluene, 50 deg C, 20 h; Yield given. Multistep reaction;
参考文献
Wei; Knaus
Synthesis, 1994 , # 12 p. 1463 - 1466
