1-Cbz-4-羟基哌啶合成路线 （共 33 条）
反应条件
1: With sodium hydroxide in 1,4-dioxane; water T=20°C; 0.5 h; 2: With hydrogenchloride in 1,4-dioxane; water pH=2;
参考文献
Piramal Life Sciences Limited
Patent: US7759387 B2, 2010 ;
Location in patent: Page/Page column 113 ;
反应条件
sodium tetrahydroborate in methanol T=0°C; 1 h;
参考文献
Dr. Reddy's Laboratories Ltd.
Patent: EP981526 B1, 2004 ;
Location in patent: Page 19 ;
反应条件
D-glucose; cells of Sphingomonas sp. HXN-200 in phosphate buffer T=30°C; pH=8.0; 3 h;
参考文献
Chang, Dongliang; Feiten, Hans-Juergen; Engesser, Karl-H.; Van Beilen, Jan B.; Witholt, Bernard; Li, Zhi
Organic Letters, 2002 , vol. 4, # 11 p. 1859 - 1862
反应条件
1-chloroethyl chlorocarbonate in methanol T=20°C; 0.5 h;
参考文献
Yeom, Chang-Eun; Kim, Young Jong; Lee, So Young; Shin, Yong Je; Kim, B. Moon
Tetrahedron, 2005 , vol. 61, # 52 p. 12227 - 12237
反应条件
in dichloromethane T=20°C; Acylation; 16 h;
参考文献
Sajiki, Hironao; Hirota, Kosaku
Tetrahedron, 1998 , vol. 54, # 46 p. 13981 - 13996
反应条件
sodium tris(acetoxy)borohydride; acetic acid in dichloromethane T=22 - 27°C; 18 h; Inert atmosphere;
参考文献
Organic Syntheses, , vol. 90, p. 74 - 86
反应条件
sodium hydroxide in diethyl ether 3 h;
参考文献
Journal of Medicinal Chemistry, , vol. 35, # 8 p. 1393 - 1398
反应条件
1: 93 percent / K2CO3 / tetrahydrofuran / 1 h 2: 33 percent / fungus Beauveria bassiana ATCC 7159, H2O / ethanol / 72 h / 25 °C View Scheme
参考文献
Journal of the Chemical Society - Perkin Transactions 1, , # 20 p. 3365 - 3370
反应条件
1: 93 percent / K2CO3 / tetrahydrofuran / 1 h 2: 33 percent / fungus Beauveria bassiana ATCC 7159, H2O / ethanol / 72 h / 25 °C View Scheme
参考文献
Journal of the Chemical Society - Perkin Transactions 1, , # 20 p. 3365 - 3370
反应条件
sodium hydroxide; dihydrogen peroxide; bis-(1,2-dimethylpropyl)borane 1.) THF, 25 deg C, 1 h, 2.) 25 deg C, 6 h; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Journal of Organic Chemistry, , vol. 50, # 10 p. 1582 - 1589
