1: With lithium hydroxide; water in tetrahydrofuran T=20°C; 2: With hydrogenchloride; water in tetrahydrofuran pH=< 7;

in tetrahydrofuran

1: tetrakis(triphenylphosphine) palladium(0); potassium fluoride / ethanol; water; N,N-dimethyl-formamide; toluene 2: iron; ammonium chloride View Scheme

1: sodium hydrogencarbonate / N,N-dimethyl-formamide 2: tetrakis(triphenylphosphine) palladium(0); potassium fluoride / ethanol; water; N,N-dimethyl-formamide; toluene 3: iron; ammonium chloride View Scheme

1: potassium hydroxide / tetrahydrofuran; methanol; water / 46 h / 20 °C / Cooling 2: S-(-)-N-methyl-alpha-methylbenzylamine / isopropanol acetate / 20 - 23 °C / Resolution of racemate 3: sodium hydrogencarbonate / N,N-dimethyl-formamide 4: tetrakis(triphenylphosphine) palladium(0); potassium fluoride / ethanol; water; N,N-dimethyl-formamide; toluene 5: iron; ammonium chloride View Scheme

1: N-ethyl-N,N-diisopropylamine; magnesium chloride / dichloromethane / 24 h / 22 °C 2: DBDMH; trifluoroacetic acid / acetonitrile / 17 h / 60 °C 3: potassium hydroxide / tetrahydrofuran; methanol; water / 46 h / 20 °C / Cooling 4: S-(-)-N-methyl-alpha-methylbenzylamine / isopropanol acetate / 20 - 23 °C / Resolution of racemate 5: sodium hydrogencarbonate / N,N-dimethyl-formamide 6: tetrakis(triphenylphosphine) palladium(0); potassium fluoride / ethanol; water; N,N-dimethyl-formamide; toluene 7: iron; ammonium chloride View Scheme

1: bromine / chloroform 2: thionyl chloride 3: AlCl3, aluminium chloride 4: sodium hydroxide 5: S-(-)-N-methyl-alpha-methylbenzylamine / isopropanol acetate / 20 - 23 °C / Resolution of racemate 6: sodium hydrogencarbonate / N,N-dimethyl-formamide 7: tetrakis(triphenylphosphine) palladium(0); potassium fluoride / ethanol; water; N,N-dimethyl-formamide; toluene 8: iron; ammonium chloride View Scheme

1: N-ethyl-N,N-diisopropylamine; magnesium chloride / dichloromethane / 24 h / 22 °C 2: DBDMH; trifluoroacetic acid / acetonitrile / 17 h / 60 °C 3: potassium hydroxide / tetrahydrofuran; methanol; water / 46 h / 20 °C / Cooling 4: S-(-)-N-methyl-alpha-methylbenzylamine / isopropanol acetate / 20 - 23 °C / Resolution of racemate 5: sodium hydrogencarbonate / N,N-dimethyl-formamide 6: tetrakis(triphenylphosphine) palladium(0); potassium fluoride / ethanol; water; N,N-dimethyl-formamide; toluene 7: iron; ammonium chloride View Scheme

1: tetrakis(triphenylphosphine) palladium(0); potassium fluoride / ethanol; water; N,N-dimethyl-formamide; toluene 2: iron; ammonium chloride View Scheme

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