(1R,2R)-2-[[4-[[(苯基氨基)羰基]氨基][1,1-联苯]-4-基]甲酰基]环戊烷羧酸合成路线 （共 7 条）
反应条件
1: With lithium hydroxide; water in tetrahydrofuran T=20°C; 2: With hydrogenchloride; water in tetrahydrofuran pH=< 7;
参考文献
US2008/15227 A1, ;
Page/Page column 17 ;
US 20080015227 A1
反应条件
dipotassium hydrogenphosphate; 1,1'-bis(di-tert-butylphosphino)ferrocene palladium dichloride in ethanol; water; N,N-dimethyl-formamide T=20°C; Suzuki-Miyaura coupling; 25 h; Inert atmosphere;
参考文献
Ravn, Matthew M.; Wagaw, Seble H.; Engstrom, Kenneth M.; Mei, Jianzhang; Kotecki, Brian; Souers, Andrew J.; Kym, Philip R.; Judd, Andrew S.; Zhao, Gang
Organic Process Research and Development, 2010 , vol. 14, # 2 p. 417 - 424
反应条件
1: potassium hydroxide / tetrahydrofuran; methanol; water / 46 h / 20 °C / Cooling 2: S-(-)-N-methyl-alpha-methylbenzylamine / isopropanol acetate / 20 - 23 °C / Resolution of racemate 3: dipotassium hydrogenphosphate; 1,1'-bis(di-tert-butylphosphino)ferrocene palladium dichloride / ethanol; water; N,N-dimethyl-formamide / 25 h / 20 °C / Inert atmosphere View Scheme
参考文献
Organic Process Research and Development, , vol. 14, # 2 p. 417 - 424
反应条件
1: N-ethyl-N,N-diisopropylamine; magnesium chloride / dichloromethane / 24 h / 22 °C 2: DBDMH; trifluoroacetic acid / acetonitrile / 17 h / 60 °C 3: potassium hydroxide / tetrahydrofuran; methanol; water / 46 h / 20 °C / Cooling 4: S-(-)-N-methyl-alpha-methylbenzylamine / isopropanol acetate / 20 - 23 °C / Resolution of racemate 5: dipotassium hydrogenphosphate; 1,1'-bis(di-tert-butylphosphino)ferrocene palladium dichloride / ethanol; water; N,N-dimethyl-formamide / 25 h / 20 °C / Inert atmosphere View Scheme
参考文献
Organic Process Research and Development, , vol. 14, # 2 p. 417 - 424
反应条件
1: bromine / chloroform 2: thionyl chloride 3: AlCl3, aluminium chloride 4: sodium hydroxide 5: S-(-)-N-methyl-alpha-methylbenzylamine / isopropanol acetate / 20 - 23 °C / Resolution of racemate 6: dipotassium hydrogenphosphate; 1,1'-bis(di-tert-butylphosphino)ferrocene palladium dichloride / ethanol; water; N,N-dimethyl-formamide / 25 h / 20 °C / Inert atmosphere View Scheme
参考文献
Organic Process Research and Development, , vol. 14, # 2 p. 417 - 424
反应条件
1: N-ethyl-N,N-diisopropylamine; magnesium chloride / dichloromethane / 24 h / 22 °C 2: DBDMH; trifluoroacetic acid / acetonitrile / 17 h / 60 °C 3: potassium hydroxide / tetrahydrofuran; methanol; water / 46 h / 20 °C / Cooling 4: S-(-)-N-methyl-alpha-methylbenzylamine / isopropanol acetate / 20 - 23 °C / Resolution of racemate 5: dipotassium hydrogenphosphate; 1,1'-bis(di-tert-butylphosphino)ferrocene palladium dichloride / ethanol; water; N,N-dimethyl-formamide / 25 h / 20 °C / Inert atmosphere View Scheme
参考文献
Organic Process Research and Development, , vol. 14, # 2 p. 417 - 424
反应条件
1: toluene / 16 h / 50 °C 2: dipotassium hydrogenphosphate; 1,1'-bis(di-tert-butylphosphino)ferrocene palladium dichloride / ethanol; water; N,N-dimethyl-formamide / 25 h / 20 °C / Inert atmosphere View Scheme
参考文献
Organic Process Research and Development, , vol. 14, # 2 p. 417 - 424
