(1S,2S)-2-(4-溴苯甲酰基)环戊烷甲酸合成路线 （共 4 条）
反应条件
1: potassium hydroxide / tetrahydrofuran; methanol; water / 46 h / 20 °C / Cooling
2: S-(-)-N-methyl-alpha-methylbenzylamine / isopropanol acetate / 20 - 23 °C / Resolution of racemate
View Scheme
参考文献
Ravn, Matthew M.; Wagaw, Seble H.; Engstrom, Kenneth M.; Mei, Jianzhang; Kotecki, Brian; Souers, Andrew J.; Kym, Philip R.; Judd, Andrew S.; Zhao, Gang
Organic Process Research and Development, 2010 , vol. 14, # 2 p. 417 - 424
反应条件
1: N-ethyl-N,N-diisopropylamine; magnesium chloride / dichloromethane / 24 h / 22 °C
2: DBDMH; trifluoroacetic acid / acetonitrile / 17 h / 60 °C
3: potassium hydroxide / tetrahydrofuran; methanol; water / 46 h / 20 °C / Cooling
4: S-(-)-N-methyl-alpha-methylbenzylamine / isopropanol acetate / 20 - 23 °C / Resolution of racemate
View Scheme
参考文献
Ravn, Matthew M.; Wagaw, Seble H.; Engstrom, Kenneth M.; Mei, Jianzhang; Kotecki, Brian; Souers, Andrew J.; Kym, Philip R.; Judd, Andrew S.; Zhao, Gang
Organic Process Research and Development, 2010 , vol. 14, # 2 p. 417 - 424
反应条件
1: bromine / chloroform
2: thionyl chloride
3: AlCl3, aluminium chloride
4: sodium hydroxide
5: S-(-)-N-methyl-alpha-methylbenzylamine / isopropanol acetate / 20 - 23 °C / Resolution of racemate
View Scheme
参考文献
Ravn, Matthew M.; Wagaw, Seble H.; Engstrom, Kenneth M.; Mei, Jianzhang; Kotecki, Brian; Souers, Andrew J.; Kym, Philip R.; Judd, Andrew S.; Zhao, Gang
Organic Process Research and Development, 2010 , vol. 14, # 2 p. 417 - 424
反应条件
1: N-ethyl-N,N-diisopropylamine; magnesium chloride / dichloromethane / 24 h / 22 °C
2: DBDMH; trifluoroacetic acid / acetonitrile / 17 h / 60 °C
3: potassium hydroxide / tetrahydrofuran; methanol; water / 46 h / 20 °C / Cooling
4: S-(-)-N-methyl-alpha-methylbenzylamine / isopropanol acetate / 20 - 23 °C / Resolution of racemate
View Scheme
参考文献
Ravn, Matthew M.; Wagaw, Seble H.; Engstrom, Kenneth M.; Mei, Jianzhang; Kotecki, Brian; Souers, Andrew J.; Kym, Philip R.; Judd, Andrew S.; Zhao, Gang
Organic Process Research and Development, 2010 , vol. 14, # 2 p. 417 - 424
