2-氨基-5-硝基苯磺酸合成路线 （共 20 条）
参考文献
Datta; Bhoumik
Journal of the American Chemical Society, 1921 , vol. 43, p. 311
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Elgersma
Recueil des Travaux Chimiques des Pays-Bas, 1929 , vol. 48, p. 766
参考文献
I. G. Farbenind.
Patent: DE686904 , 1937 ;
DRP/DRBP Org.Chem.
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Gen. Aniline and Film Corp.
Patent: US2206510 , 1938 ;
反应条件
hydrogenchloride; iodine cloride
参考文献
Boyle
Journal of the Chemical Society, 1911 , vol. 99, p. 333
参考文献
Boyle
Journal of the Chemical Society, 1911 , vol. 99, p. 333
反应条件
1.1: trichlorophosphate / sulfolane / 80 - 120 °C
1.2: 10 - 95 °C
1.3: 25 - 80 °C / pH 6 - 8
2.1: hydrogen / palladium 10 on activated carbon / tetrahydrofuran; methanol / 23 °C / 2585.81 Torr / Industry scale; Autoclave
3.1: pyridine / dichloromethane / 0 - 23 °C / Industry scale
4.1: tetrahydrofuran / 1 h / 0 - 23 °C / Industry scale
5.1: sodium hydroxide; water / 30 h / 23 °C / Industry scale
5.2: 0 °C / Industry scale
View Scheme
参考文献
ANADYS PHARMACEUTICALS, INC.
Patent: WO2008/124450 A1, 2008 ;
反应条件
1: With trichlorophosphate in sulfolane
T=80 - 120°C;
2: With ammonium hydroxide in sulfolane; water
T=10 - 95°C;
参考文献
ANADYS PHARMACEUTICALS, INC.
Patent: WO2008/124450 A1, 2008 ;
Location in patent: Page/Page column 69-70 ;
参考文献
Claasz
Justus Liebigs Annalen der Chemie, 1911 , vol. 380, p. 312
反应条件
(i) PCl5, (ii) Na2SO3, aq. NaOH; Multistep reaction;
参考文献
Hoffmann,R.W. et al. Chemische Berichte, 1965 , vol. 98, p. 2074 - 2085
反应条件
Multi-step reaction with 4 steps 1.1: trichlorophosphate / sulfolane / 80 - 120 °C1.2: 10 - 95 °C1.3: 25 - 80 °C / pH 6 - 82.1: hydrogen / palladium 10 on activated carbon / tetrahydrofuran; methanol / 23 °C / 2585.81 Torr / Industry scale; Autoclave3.1: pyridine / dichloromethane / 0 - 23 °C / Industry scale4.1: diethyl ether; isobutyramide / 1 h / 25 °C
参考文献
ANADYS PHARMACEUTICALS, INC. Patent: WO2008/124450 A1, 2008 ;
反应条件
Multi-step reaction with 4 steps 1.1: trichlorophosphate / sulfolane / 80 - 120 °C1.2: 10 - 95 °C1.3: 25 - 80 °C / pH 6 - 82.1: hydrogen / palladium 10 on activated carbon / tetrahydrofuran; methanol / 23 °C / 2585.81 Torr / Industry scale; Autoclave3.1: pyridine / dichloromethane / 0 - 23 °C / Industry scale4.1: tetrahydrofuran / 1 h / 0 - 23 °C / Industry scale
参考文献
ANADYS PHARMACEUTICALS, INC. Patent: WO2008/124450 A1, 2008 ;
