4-甲氧基-2-硝基苯胺合成路线 （共 138 条）
反应条件
1: 88 percent / CuBr2, t-BuONO / acetonitrile 2: Fe, HCl / ethanol 3: NaHCO3 / dimethylformamide 4: 1) t-BuLi, Cp2Zr(CH3)Cl, 2) I2 / 1) THF, -78 to 45 deg C, 2) CH2Cl2, 0 deg C 5: 86 percent / BBr3 / CH2Cl2 View Scheme
参考文献
Tidwell, Jeffrey H.; Buchwald, Stephen L.
Journal of Organic Chemistry, 1992 , vol. 57, # 24 p. 6380 - 6382
反应条件
sodium hydroxide in ethanol; water T=70°C; 1.5 h; Green chemistry;
参考文献
Pu, Shuai; Liang, Qiuxiang; Luo, Xi; Luo, Juan
Journal of Chemical Research, 2014 , vol. 38, # 2 p. 118 - 120
反应条件
tin(ll) chloride T=130°C; 0.0833333 h; microwave;
参考文献
VanVliet, David S.; Gillespie, Paul; Scicinski, Jan J.
Tetrahedron Letters, 2005 , vol. 46, # 39 p. 6741 - 6743
反应条件
1: 2-nitro-4-methoxy-aniline With hydrogenchloride in water 0.333333 h; Heating; 2: With sodium nitrite in water 0.5 h; 3: potassium cyanide With copper (I) cyanide in water 2 h; Heating; Further stages.;
参考文献
Gallou-Dagommer, Isabelle; Gastaud, Philippe; RajanBabu
Organic Letters, 2001 , vol. 3, # 13 p. 2053 - 2056
反应条件
1: 2-nitro-4-methoxy-aniline With hydrogenchloride; sodium nitrite in water T=0°C; 0.5 h; 2: copper (I) cyanide With sodium cyanide in water T=20°C; Sandmeyer reaction; 1 h; Further stages.;
参考文献
Pletnev, Alexandre A.; Tian, Qingping; Larock, Richard C.
Journal of Organic Chemistry, 2002 , vol. 67, # 26 p. 9276 - 9287
反应条件
water; nickel dichloride
参考文献
Stephen et al.
Journal of the Chemical Society, 1947 , p. 1034,1037
反应条件
1.1: sulfuric acid; acetic acid; sodium nitrite / water / 15 - 20 °C 1.2: 20 - 80 °C 2.1: hydrogenchloride; iron / ethanol; water / 3 h / Reflux 3.1: TMADCl / ethyl acetate / 96 h 4.1: triethylamine; triphenylphosphine; bis(dibenzylideneacetone)-palladium(0) / 1,4-dioxane / 80 °C / Inert atmosphere; Sealed chamber View Scheme
参考文献
Journal of the American Chemical Society, , vol. 133, # 15 p. 6061 - 6071
反应条件
1.1: NaNO2; HCl / H2O / 0.5 h / 0 °C 1.2: NaCN / H2O / 1 h / 20 °C 2.1: 100 percent / SnCl2; AcOH / 1,2-dimethoxy-ethane; ethanol / 3 h / 65 °C View Scheme
参考文献
Bradford et al.
Journal of the Chemical Society, 1947 , p. 437,44
反应条件
indium; acetic acid in ethyl acetate 2 h; RefluxInert atmosphere;
参考文献
Kim, Jaeho; Kim, Jihye; Lee, Hyunseung; Lee, Byung Min; Kim, Byeong Hyo
Tetrahedron, 2011 , vol. 67, # 41 p. 8027 - 8033
反应条件
tin(ll) chloride T=130°C; 0.0833333 h; microwave;
参考文献
VanVliet, David S.; Gillespie, Paul; Scicinski, Jan J.
Tetrahedron Letters, 2005 , vol. 46, # 39 p. 6741 - 6743
