4-氯-3-硝基苯甲酸合成路线 （共 122 条）
反应条件
1: sulfuric acid / 4 h / Reflux
2: NH2NH2•xH2O / ethanol / 8 h / Reflux
View Scheme
参考文献
Hasan, Aurangzeb; Akhtar, Mohammad Nadeem; Gapil, Shelly
Asian Journal of Chemistry, 2011 , vol. 23, # 12 p. 5471 - 5476
反应条件
1: aqueous NaOH; sodium polysulfide / anschliessend mit CS2 erwaermen
2: aqueous NaClO; aqueous NaOH / Behandeln des Reaktionsprodukts mit N2H4+H2O in H2O
View Scheme
参考文献
Solow'ewa et al.
Zhurnal Obshchei Khimii, 1956 , vol. 26, p. 3036,3039, 3041; engl. Ausg. S. 3383, 3385,3387
反应条件
1: HCl
2: 78 percent / dimethylformamide / 80 °C
View Scheme
参考文献
Oezden, Seckin; Atabey, Dilek; Yildiz, Sulhiye; Goeker, Hakan
Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 5 p. 1587 - 1597
反应条件
1: HCl
2: 78 percent / dimethylformamide / 80 °C
3: 93 percent / H2 / Pd/C / ethanol / 2068.59 Torr
View Scheme
参考文献
Oezden, Seckin; Atabey, Dilek; Yildiz, Sulhiye; Goeker, Hakan
Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 5 p. 1587 - 1597
反应条件
1: HCl
2: 84 percent / dimethylformamide / 80 °C
3: 94 percent / H2 / Pd/C / ethanol / 2068.59 Torr
View Scheme
参考文献
Oezden, Seckin; Atabey, Dilek; Yildiz, Sulhiye; Goeker, Hakan
Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 5 p. 1587 - 1597
反应条件
1: HCl
2: 71 percent / dimethylformamide / 80 °C
3: 93 percent / H2 / Pd/C / ethanol / 2068.59 Torr
View Scheme
参考文献
Oezden, Seckin; Atabey, Dilek; Yildiz, Sulhiye; Goeker, Hakan
Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 5 p. 1587 - 1597
反应条件
1: 95 percent / HCl gas / Heating
2: 84 percent / tetrahydrofuran / 2 h / 40 °C
View Scheme
参考文献
Ates-Alagoz, Zeynep; Buyukbingol, Erdem
Heterocyclic Communications, 2001 , vol. 7, # 5 p. 455 - 460
反应条件
1: phosphorus pentachloride
2: pyridine
3: pyridine; potassium hydroxide
4: sulfuric acid; acetic acid / 1 h / |Reflux
View Scheme
参考文献
Joshi, Akshada J.; Gadhwal, Manoj K.; Joshi, Urmila J.; D'Mello, Priscilla; Sinha, Ragini; Govil, Girjesh
Medicinal Chemistry Research, 2013 , vol. 22, # 9 p. 4293 - 4299
反应条件
1: 79 percent / NaOH / ethanol / 4 h / Heating
2: 73.5 percent / 4 h / Heating
3: 69.5 percent / KOH, / ethanol; acetone / 2.5 h / Heating
View Scheme
参考文献
Gupta; Kalwania; Kumar
Journal of Heterocyclic Chemistry, 1984 , vol. 21, # 3 p. 893 - 896
反应条件
1: 4-chloro-3-nitro-benzoic acid With caesium carbonate; Merrifield resin in N,N-dimethyl-formamide
T=50°C; 24 h;
2: vinyl-magnesium bromide in tetrahydrofuran
T=-40 - 0°C; Bartoli reaction;
3: methanol With sodium methylate in tetrahydrofuran
T=25°C; 3 h;
参考文献
Knepper, Kerstin; Braese, Stefan
Organic Letters, 2003 , vol. 5, # 16 p. 2829 - 2832
